Table 3.

Summary of the association results of two SNPs in the eight lung cancer GWASs

Study population	Sample size		Imputation quality	rs151606 A > T		Imputation quality	rs12212247 T > C
	Cases	Controls		OR (95% CI)	P		OR (95% CI)	P
TRICL combineda	12 160	16 838		1.12 (1.07–1.17)	1.18E−06		0.93 (0.90–0.97)	8.93E−05
ICRb	1952	5200	0.74	1.19 (1.09–1.30)	1.24E−04	0.99	0.93 (0.86–1.00)	4.44E−02
MDACCc	1150	1134	0.45	1.10 (0.92–1.32)	3.10E−01	0.96	0.95 (0.84–1.07)	3.94E−01
IARCd	2533	3791	0.44	1.04 (0.93–1.17)	5.23E−01	0.98	0.97 (0.90–1.04)	3.52E−01
NCIe	5713	5736	0.72	1.10 (1.03–1.18)	3.28E−03	0.99	0.94 (0.89–0.99)	1.88E−02
Torontof	331	499	0.70	1.19 (0.91–1.57)	2.06E−01	0.99	0.82 (0.66–1.02)	7.60E−02
GLCg	481	478	0.52	1.16 (0.89–1.50)	2.78E−01	0.98	0.78 (0.65–0.94)	9.02E−03
Replication combineda	2303	27 350		1.02 (0.93–1.11)	7.19E−01		0.93 (0.87–1.00)	3.90E−02
Harvardh	984	970	0.75	1.15 (0.95–1.39)	1.50E−01	1.00	0.88 (0.76–1.01)	5.91E−02
DeCODEi	1319	26 380	0.75	0.98 (0.89–1.08)	7.50E−01	1.00	0.95 (0.88–1.03)	1.96E−01
All combineda	14 463	44 188		1.10 (1.05–1.14)	8.03E−06		0.93 (0.90–0.96)	9.59E−06

GWAS, genome-wide association study; SNP, single-nucleotide polymorphism.

^aThe combined OR and P value were estimated using a fixed effects model.

^bICR: the Institute of Cancer Research Genome-wide Association Study, UK.

^cMDACC: the MD Anderson Cancer Center Genome-wide Association Study, USA.

^dIARC: the International Agency for Research on Cancer Genome-wide Association Study, France;

^eNCI: the National Cancer Institute Genome-wide Association Study, USA.

^fToronto: the Lunenfeld-Tanenbaum Research Institute Genome-wide Association Study, Toronto, Canada.

^gGLC: German Lung Cancer Study, Germany.

^hHarvard: Harvard Lung Cancer Study, USA.

ⁱdeCODE: Icelandic Lung Cancer Study, Iceland.