Table 1. Included trials.

Protocol	Group	n	% Females	% Completers	Trial duration	Trial period	Comments
GSK/002	PRX IR FLEX	162	49	67	6 Weeks	1985–1987
	PLA	162	54	54
GSK/003	PRX IR FLEX	234	53	57	6 Weeks	1985–1986
	PLA	234	49	47
GSK/115	FLX FLEX	274	65	76	12 Weeks	1991
	PRX IR FLEX	272	64	73
	PLA	111	72	78
GSK/128	FLX FLEX	343	61	75	12 Weeks	1991
	PRX IR FLEX	347	61	74
	PLA	135	71	84
GSK/251	PRX IR FLEX	120	68	74	8 Weeks	1992–1993
	PLA	123	64	76
GSK/448	PRX CR FLEX	102	60	77	12 Weeks	1996–1997
	PRX IR FLEX	104	64	74
	PLA	101	66	85
GSK/449	PRX CR FLEX	108	67	85	12 Weeks	1996–1997
	PRX IR FLEX	110	74	80
	PLA	110	60	83
GSK/487	PRX CR FLEX	103	48	84	12 Weeks	1996–1997	≥ 60 Years
	PRX IR FLEX	103	55	87
	PLA	107	63	88
GSK/810	PRX CR 12.5 mg	151	54	89	8 Weeks	2001–2002	≥ 60 Years
	PRX CR 25.0 mg	143	60	83
	PLA	142	62	86
GSK/874	PRX CR 12.5 mg	161	59	77a	10 Weeks	2003–2004	≥ 60 Years; no evaluation at week 6; week 8 data used.
	PRX CR 25.0 mg	173	60	82a
	PLA	178	64	71a
LB/85A	CIT FLEX	82	35	59b	4 Weeks	1984–1985	Four-week trial; week 4 data used.
	PLA	87	33	59b
LB/89303	CIT 20 mg	68	68	75	6 Weeks	1989–1990
	CIT 40 mg	61	74	80
	PLA	64	67	72
LB/91206	CIT 10 mg	125	63	91	6 Weeks	1992–1993
	CIT 20 mg	128	66	91
	CIT 40 mg	127	61	91
	CIT 60 mg	119	51	89
	PLA	124	57	90
PZ/103	SER 50 mg	94	52	63	6 Weeks	1984–1985
	SER 100 mg	93	56	50
	SER 200 mg	74	64	51
	PLA	86	44	56
PZ/104	SER FLEX	142	54	67	8 Weeks	1984–1986
	PLA	141	42	65
PZ/109	SER FLEX	104	60	64	8 Weeks	1987–1989
	PLA	103	66	61
PZ/111	FLX FLEX	108	67	74	8 Weeks	1989–1990
	SER FLEX	106	75	64
	PLA	105	65	65
PZ/315	SER FLEX	76	66	61	8 Weeks	1984–1986
	PLA	73	80	63

Abbreviations: CIT, citalopram; FLEX, flexible dosage; FLX, fluoxetine; PLA, placebo; PRX CR, paroxetine continuous release; PRX IR, paroxetine immediate release; SER, sertraline. % Completers=completers at week 6.

^aCompleters at week 8.

^bCompleters at week 4.