Figure 4.
Knockdown of Nf1 causes night hyperactivity, resembling DAT and latrophilin knockdown phenotypes. (a) Pan-neuronal knockdown of Nf1 (v109637/UAS-Dcr-2; +/elav-GAL4, n=36) gives rise to hyperactivity in the dark, compared to its genetic background control (v60100/UAS-Dcr-2; +/elav-GAL4, n=31). (a') ΔActivity and Δsleep is most severely affected during darkness, like in DAT and latrophilin knockdowns (see Figures 2a' and b').