Table 2. The altered metabolites detected by RP-UPLC-MS of non-polar extracts of liver from CUMS-treated rat and their variation tendency.
| NO. | Metabolites | Rt _Mass | VIP | Trend | Metabolic pathway |
|---|---|---|---|---|---|
| L1 | PA(44:3)+ | 6.53_810.6000 | 5.4 | ↑** | Phospholipid metabolism |
| L2 | PG(P-18:0/22:4)+ | 6.95_810.5998 | 4.7 | ↑* | Phospholipid metabolism |
| L3 | TG(45:2)+ | 7.97_760.5845 | 10.2 | ↑** | Lipid metabolism |
| L4 | PC(36:2)+ | 8.17_786.6004 | 6.5 | ↑** | Phospholipid metabolism |
| L5 | PC(36:4)+ | 11.03_782.5687 | 6.3 | ↑** | Phospholipid metabolism |
| L6 | PE(36:4)+ | 11.24_740.5218 | 5.9 | ↑** | Phospholipid metabolism |
| L7 | PC(36:3)+ | 11.65_784.5839 | 11.2 | ↑** | Phospholipid metabolism |
| L8 | PC(40:2)− | 7.13_878.5911 | 6.5 | ↑** | Phospholipid metabolism |
| L9 | PE(44:2)− | 8.94_854.5913 | 22.4 | ↑** | Glycerophospholipid metabolism |
| L10 | PC(35:4)− | 9.41_766.5380 | 14.5 | ↑* | Glycerophospholipid metabolism |
| L11 | PE(38:4)− | 9.67_766.5385 | 8.5 | ↑** | Glycerophospholipid metabolism |
| L12 | PC(20:3/P-16:0)− | 9.72_804.5754 | 4.3 | ↑** | Glycerophospholipid metabolism |
| L13 | PG(34:1)− | 11.38_747.5657 | 5.8 | ↑** | Glycerolipid metabolism |
| L14 | PE(38:5)− | 12.07_764.5224 | 7.1 | ↑* | Glycerophospholipid metabolism |
“+” represent the metabolites detected in positive mode;
“−” metabolites detected in negative mode.
*p < 0.05, **p < 0.01 compared with control group.