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. 2016 Mar 23;6:23417. doi: 10.1038/srep23417

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A cartoon of two subunits of a tetrameric hEAG1 channel complex shown in the open (left) and closed (right) states. PIP₂ (red) binding to the CaM-N segment (blue) may cause a conformational change of the complex formed by EAG domain and CNBHD and then close the channel gate via the C-linker region as described in Haitin et al.¹³.