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. 2016 Mar 23;6:23481. doi: 10.1038/srep23481

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(A) Representative samples of CSD in adult rat cortex in the untreated area from electrode DC 1 at the site of KCl microinjection, and electrode DC 2 (about 800 μm away) and from electrode DC 3 in the treated area (about 10 mm away from CSD elicitation) before and after application of 1 μg Anakinra. (B) Superfusion of a brain area with Anakinra prevents the effect of IL-1ß on CSD, stabilizing CSD amplitudes. Bars represent mean CSD amplitudes ± S.E.M. at different time points with topical application of Anakinra (n = 3).