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. 2016 Mar 23;6:23480. doi: 10.1038/srep23480

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(a) Age-related changes in the effect of loading on formed (top) and resorbed (bottom) bone volume. *Significant difference between endocortical and periosteal surface. Arrow: nearly no resorption in young animals. (b) Changes and interplay of bone formation (MV/BV) and resorption volumes (EV/BV) over 15 days in loaded tibiae from young, adult and elderly mice. *Significant difference formation vs. resorption. ^#Significant difference formation between regions. ⁺Significant difference in resorption between regions. ^§Indicates an effect of aging on adaptive bone formation. Shaded regions correspond to standard deviations. (c) Total static changes occurring over 15 days. ⁺significant difference endocortical vs. periosteal surface. ^*Significant difference loaded vs. control limbs. ^#Significant difference day 0 vs. day 15.