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. 2016 Mar 23;6:23496. doi: 10.1038/srep23496

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Copyright © 2016, Macmillan Publishers Limited

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(a–d) Lateral views of control (a,b) and kctd10 and gRNA injected lamprey larvae (c,d) on 21 dpf (days post fertilization). The control larvae have normal heart formation (a) and the treatment larvae have severe pericardial edema (c). (b,d) enlarged views of a and c, respectively, provide a comparison that shows the marked heart malformations in the injected larvae (d). (d) the atrium (a) stretches to a string-like structure and no blood was observed in either atrium or ventricle (v). Zebrafish larvae of kctd10 mutant had pericardial edema (g) and heart malformations (h) as compared to the wild-type larvae (e,f) on 2.5 dpf. In the mutants, part of the atrium stretches to a string-like structure and no blood was observed in either atrium or ventricle (h). Scale bars: 0.2 mm.