Table 1.
Strains | OA | EA | Total | DIFF | POAE | POAT | OAAI | References |
---|---|---|---|---|---|---|---|---|
C57BL/6JOla | 12.0 | 2.8 | 14.8 | −9.2 | 81 | 61 | 29 | Mathiasen et al. 2008 (T2) |
BALB/cByJ | 17.0 | 8.0 | 25.0 | −9.0 | 68 | 90 | 21 | Trullas and Skolnick 1993 |
BALBc/J | 6.4 | 1.6 | 8.0 | −4.8 | 80 | 69 | 26 | Trullas and Skolnick 1993 |
C57BL/6JOla | 10.0 | 5.3 | 15.3 | −4.7 | 65 | 46 | 44 | Mathiasen et al. 2008 (T1) |
C3H/HeN | 10.4 | 6.6 | 17.0 | −3.7 | 61 | 52 | 44 | Trullas and Skolnick 1993 |
CBA/J | 9.6 | 6.4 | 16.0 | −3.2 | 60 | 58 | 41 | Trullas and Skolnick 1993 |
C3H/HeJ | 8.4 | 5.6 | 14.0 | −2.8 | 60 | 69 | 36 | Trullas and Skolnick 1993 |
NMRI | 8.7 | 6.3 | 15.0 | −2.4 | 58 | 37 | 53 | Griebel et al. 2000 |
NMRI | 8.3 | 6.9 | 15.2 | −1.4 | 55 | 40 | 53 | Mathiasen et al. 2008 (T2) |
NMRI | 9.2 | 9.3 | 18.6 | 0.1 | 49 | 38 | 56 | Mathiasen et al. 2008 (T1) |
C3H/HeJ | 1.5 | 2.5 | 4.0 | 1.0 | 37 | 29 | 67 | Griebel et al. 2000 |
C3H/HeJ | 1.5 | 3.0 | 4.5 | 1.5 | 33 | 13 | 77 | Yilmazer–Hanke et al. 2003 |
SJL/J | 8.7 | 10.3 | 19.0 | 1.5 | 46 | 23 | 66 | Griebel et al. 2000 |
C57BL/6J | 3.5 | 5.5 | 9.0 | 2.0 | 39 | 1 | 80 | Yilmazer–Hanke et al. 2003 |
CBA/J | 2.6 | 5.4 | 8.0 | 2.9 | 32 | 28 | 70 | Griebel et al. 2000 |
BALB/cByJ | 3.6 | 7.4 | 11.0 | 3.7 | 33 | 15 | 76 | Griebel et al. 2000 |
DBA/2Ola | 7.3 | 11.6 | 18.9 | 4.3 | 39 | 43 | 59 | Mathiasen et al. 2008 (T1) |
BALB/cJ | 6.5 | 11.0 | 17.0 | 4.5 | 38 | 21 | 70 | Yilmazer–Hanke et al. 2003 |
A/J | 3.0 | 8.0 | 11.0 | 5.1 | 27 | 65 | 54 | O'Leary et al. 2013 |
DBA | 2.4 | 7.6 | 10.0 | 5.2 | 24 | 11 | 83 | Griebel et al. 2000 |
DBA/2Ola | 4.9 | 10.3 | 15.2 | 5.4 | 32 | 66 | 51 | Mathiasen et al. 2008 (T2) |
BALBc/J | 7.8 | 13.2 | 21.0 | 5.5 | 37 | 21 | 71 | O'Leary et al. 2013 |
DBA/2J | 2.8 | 8.3 | 11.0 | 5.5 | 25 | 62 | 57 | Trullas and Skolnick 1993 |
NMRI | 6.0 | 11.5 | 17.5 | 5.5 | 34 | 34 | 66 | Yilmazer–Hanke et al. 2003 |
BALB/cByJ | 8.1 | 13.9 | 22.0 | 5.7 | 37 | 41 | 61 | O'Leary et al. 2013 |
C3H/HeJ | 8.8 | 16.3 | 25.0 | 7.5 | 35 | 42 | 62 | O'Leary et al. 2013 |
A/J | 0.2 | 7.8 | 8.0 | 7.7 | 2 | 27 | 86 | Trullas and Skolnick 1993 |
C57BL/6J | 3.5 | 11.6 | 15.0 | 8.1 | 23 | 37 | 70 | Griebel et al. 2000 |
C57BL/6ByJ | 2.2 | 10.8 | 13.0 | 8.6 | 17 | 34 | 75 | Trullas and Skolnick 1993 |
DBA/2J | 2.5 | 13.5 | 16.0 | 11.0 | 16 | 36 | 74 | Yilmazer–Hanke et al. 2003 |
C57BL/6J | 0.8 | 13.2 | 14.0 | 12.3 | 6 | 35 | 80 | Trullas and Skolnick 1993 |
129S1/SvImJ | 6.3 | 18.8 | 25.0 | 12.5 | 25 | 5 | 85 | O'Leary et al. 2013 |
C57BL/6J | 7.2 | 22.8 | 30.0 | 15.6 | 24 | 19 | 79 | O'Leary et al. 2013 |
SJL/J | 11.3 | 27.7 | 39.0 | 16.4 | 29 | 35 | 68 | O'Leary et al. 2013 |
DBA/2J | 7.7 | 24.3 | 32.0 | 16.6 | 24 | 6 | 85 | O'Leary et al. 2013 |
AKR | 5.8 | 23.2 | 29.0 | 17.4 | 20 | 36 | 72 | O'Leary et al. 2013 |
FVB/NJ | 9.8 | 31.2 | 41.0 | 21.3 | 24 | 15 | 81 | O'Leary et al. 2013 |
BTBR | 7.4 | 29.6 | 37.0 | 22.2 | 20 | 46 | 67 | O'Leary et al. 2013 |
The above data were mostly estimated from average group values of available test parameters in tables or graphs. They are presented in the order of the difference (DIFF) between open arm (OA) and enclosed arms (EA) entries. Negative values indicate a preference for open arms. T1 and T2 in Mathiasen et al. 2008 refer to Table 1 and table 2, respectively. The above data sample demonstrates lack of concordance between the EPM test parameters. It also demonstrates that the same strain of mice can be low anxiety in one study and high anxiety in another one. Note also that, in most research reports, the POAE and POAT are below 50%.
OA, open arm entries; EA, enclosed arm entries; Total, OA + EA; DIFF, EA‐OA; POAE, percent open arm entries; POAT, percent open arm time; OAAI, open arm avoidance index.