Supplementary Figure 6.

The cis-acting (gene structure and gene function) and trans-acting (the F gene → the B gene → the A gene) of genes. This figure explains why we did not find susceptibility genes from the candidate genes involved in the pathogenesis of the disease. We cannot elucidate the pathogenesis of the disease using the susceptibility genes that were detected in the genome-wide scan. However, it is likely that the susceptibility gene primarily exerts its effect via interaction between genes (trans-acting).