Table 1.
Characteristics of randomized controlled trials included in the systemic review
| Included studies | Arm | Means of intervention | Male/female (n) | Age (years), range | Time (days) | Outcome |
|---|---|---|---|---|---|---|
| Xing et al. 2014[12] | EG | NVB 25 mg/m2 + DDP 80 mg/m2 + Aidi 50 ml | 36/24 | 62–78 | ≥42 | ①②③④⑧⑨ |
| CG | NVB 25 mg/m2 + DDP 80 mg/m2 | 38/22 | 64–77 | |||
| Huang et al. 2008[13] | EG | NVB 25 mg/m2 + DDP 30 mg/m2 + Aidi 50 ml | – | – | 56 | ①②③⑧ |
| CG | NVB 25 mg/m2 + DDP 30 mg/m2 | – | – | |||
| Xu et al. 2013[14] | EG | NVB 25 mg/m2 + DDP 80 mg/m2 + Aidi 100 ml | 27/8 | 35–75 | ≥42 | ①②③④⑤ |
| CG | NVB 25 mg/m2 + DDP 80 mg/m2 | 26/9 | 33–76 | |||
| Zhang et al. 2005[15] | EG | NVB 25 mg/m2 + DDP 30 mg/m2 + Aidi 50 ml | – | – | 21 | ①②⑧ |
| CG | NVB 25 mg/m2 + DDP 30 mg/m2 | – | – | |||
| Xu et al. 2007[16] | EG | NVB 25 mg/m2 + DDP 40 mg/m2 + Aidi 50 ml | – | – | 84 | ①③④ |
| CG | NVB 25 mg/m2 + DDP 40 mg/m2 | – | – | |||
| Cui and Wang 2005[17] | EG | NVB 25 mg/m2 + DDP 80 mg/m2 + Aidi 50 ml | – | – | ≥42 | ①②③④⑧⑨ |
| CG | NVB 25 mg/m2 + DDP 80 mg/m2 | – | – | |||
| Zhang et al. 2006[18] | EG | NVB 25 mg/m2 + DDP 30 mg/m2 + Aidi 50 ml | – | – | ≥84 | ①②③④ |
| CG | NVB 25 mg/m2 + DDP 30 mg/m2 | – | – | |||
| Xia et al. 2014[19] | EG | NVB 25 mg/m2 + DDP 25 mg/m2 + Aidi 50 ml | 15/8 | – | 21 | ①②③④ |
| CG | NVB 25 mg/m2 + DDP 25 mg/m2 | 14/9 | – | |||
| Zhao and Yang 2009[20] | EG | NVB 25 mg/m2 + DDP 35 mg/m2 + Aidi 50 ml | 28/12 | – | ≥30 | ①②③④ |
| CG | NVB 25 mg/m2 + DDP 35 mg/m2 | 30/13 | – | |||
| Zhang et al. 2003[21] | EG | NVB 25 mg/m2 + DDP 20–40 mg/m2 + Aidi 40–50 ml | 36/13 | 63.0 ± 7.8 | ≥42 | ①②③④ |
| CG | NVB 25 mg/m2 + DDP 20–40 mg/m2 | 38/11 | 63.0 ± 7.9 | |||
| Zhang and Lu 2014[22] | EG | NVB 25 mg/m2 + DDP 25 mg/m2 + Aidi 50 ml | 32/13 | 40–79 | 42 | ①②③④⑤ |
| CG | NVB 25 mg/m2 + DDP25 mg/m2 | 31/14 | 40–79 | |||
| Wang et al. 2004[23] | EG | NVB 30 mg/m2 + DDP 120 mg/m2 + Aidi 40 ml | – | – | 84 | ①②③⑧ |
| CG | NVB 30 mg/m2 + DDP 120 mg/m2 | – | – |
Values are n or mean ± SD or range. EG: Experimental group; CG: Control group; NVB: Vinorelbine; DDP: Cisplatin; –: Unclear. Outcome: ①efficacy rate; ②quality of life; ③myelosuppression; ④gastrointestinal reaction; ⑤damage of liver and kidney; ⑥neurotoxicity; ⑦alopecia; ⑧immune function; ⑨Phlebitis.