Table 2.

Qualitative Analysis of Included Studies^a

Source	Adequate Sequence Generation Described	Allocation Concealment Described	Assessor Blinding Described	Incomplete Outcome Data Addressed	Free From Selective Reporting	Free From Other Bias	Eligibility Criteria Defined	Excluded Patients Described	All Therapies Described	Jadad Quality Scoreb
Aaron et al,35 2007	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	5
Burge et al,10 2000	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	4
Calverley et al,11 2003	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	3
Calverley et al,12 2007	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	5
Kardos et al,13 2007	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	4
Lung Health Study Research Group,34 2000	Unclear	Unclear	Yes	Unclear	Yes	Yes	Yes	Yes	Yes	3
Pauwels et al,36 1999	Unclear	Unclear	Yes	Yes	Yes	Yes	Yes	Yes	Yes	3
Szafranski et al,14 2003	Unclear	Unclear	Yes	Unclear	Yes	No	Yes	Yes	Yes	3
Vestbo et al,37 1999	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	5
Wedzicha et al,15 2008	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	5
Zheng et al,16 2007	Unclear	Unclear	Yes	Yes	Yes	Yes	Yes	Yes	Yes	3

^aQualitative assessment was performed using the Cochrane bias assessment method.³⁰ Assessment of each criteria could be “yes,” “no,” or “unclear.”

^bRange, 1–5; 5 indicates highest quality.³¹