. Author manuscript; available in PMC: 2017 Feb 1.

Published in final edited form as: Microbiol Spectr. 2016 Feb;4(1):10.1128/microbiolspec.VMBF-0006-2015. doi: 10.1128/microbiolspec.VMBF-0006-2015

Table 1.

Human antimicrobial peptides and murine cathelicidin mCRAMP.

Class	Peptide	Gene	Species	Producing Cells	Reference(s)	Amino Acid Sequence^*
α-defensins	HNP-1	DEFA1	Human	Azurophilic granules of neutrophil granulocytes	(14)	AC₁YC₂RIPAC₃IAGERRYGTC₂IYQGRLWAFC₃C₁
	HNP-2	DEFA1	Human			C₁YC₂RIPAC₃IAGERRYGTC₂IYQGRLWAFC₃C₁
	HNP-3	DEFA3	Human			DC₁YC₂RIPAC₃IAGERRYGTC₂IYQGRLWAFC₃C₁
	HNP-4	DEFA4	Human			VC₁SC₂RLVFC₃RRTELRVGNC₂LIGGVSFTYC₃C₁TRV
	HD-5	DEFA5	Human	Paneth cells in small intestine and female urogenital tract	(15, 16)	ATC₁YC₂RTGRC₃ATRESLSGVC₂EISGRLYRLC₃C₁R
	HD-6	DEFA6	Human	Paneth cells in small intestine and female urogenital tract	(15, 16)	AFTC₁HC₂RRSC₃YSTEYSYGTC₂TVMGINHRFC₃C₁L
β-defensins	HBD-1	DEFB1	Human	Epithelial cells, monocytes, macrophages and dendritic cells	(11, 17)	DHYNC₁VSSGGQC₂LYSAC₃PIFTKIQGTC₂YRGKAKC₁C₃K
	HBD-2	DEFB4	Human			GIGDPVTC₁LKSGAIC₂HPVFC₃PRRYKQIGTC₂GLPGTKC₁C₃KKP
	HBD-3	DEFB103	Human			GIINTLQKYYC₁RVRGGRC₂AVLSC₃LPKEEQIGKC₂STRGRKC₁C₃RRKK
	HBD-4	DEFB104	Human			ELDRIC₁GYGTARC₂RKKC₃RSQEYRIGRC₂PNTYAC₁C₃LRK
Cathelicidins	LL-37	CAMP	Human	Skin cells, gastrointestinal cells, neutrophils and myeloid bone marrow cells	(18)	LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
	mCRAMP	Cnlp	Murine		(18)	GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ
Others	C18G	n/a	Synthetic	n/a	(253)	ALYKKLLKKLLKSAKKLG

Numbers denote cysteine residues involved in disulfide bonds.

Abbreviations: HNP-1, human neutrophil defensin 1; HNP-2, human neutrophil defensin 2; HNP-3, human neutrophil defensin-3; HNP-4, human neutrophil defensin-4; HD-5, human α-defensin-5; HD-6, human α-defensin-6; HBD-1, human β-defensin 1, HBD-2, human β-defensin 2; HBD-3, human β-defensin-3; HBD-4, human β-defensin-4; LL-37, human cathelicidin; mCRAMP, murine cathelicidin-related peptides; C18G, α-helical peptide derived from the carboxy terminus of platelet factor IV. Modified from Gruenheid and Moual 2012 (229).