TABLE II. Cytokines median levels (pg/mL) in patients with dengue according to the days of disease.
| 0-2 days | p | 3-5 days | p | ||||
|---|---|---|---|---|---|---|---|
|
|
|
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| DF | DHF | DF | DHF | ||||
| IL-12p70 | DENV1 | 26.6 (22.7-52.7) | 23.8 (22.7-35.8) | 0.056 | 23.1 (22.7-36.8) | 23.6 (22.7-42.8) | NS |
| DENV2 | 26.1 (20.1-33.5) | 29.3 (23.9-32.6) | NS | 26.4 (22.7-32.4) | 31.8 (22.7-50.1) | 0.034 | |
| IFN-g | DENV1 | 44.2 (40.3-50.7) | 44.7 (40.2-120.0) | NS | 43.4 (40.2-95.6) | 45.4 (41.5-118) | 0.042 |
| DENV2 | 45.6 (39.2-64.1) | 46.1 (42.5-73.6) | NS | 44.7 (40.2-58.5) | 51.9 (44.5-68.2) | 0.026 | |
| TNF-a | DENV1 | 3.9 (0.03-18.7) | 2.4 (0.94-6.3) | 0.009 | 2.0 (0.83-6.3) | 2.4 (0.72-8.4) | NS |
| DENV2 | 3.6 (0.36-9.8) | 5.3 (3.7-6.8) | 0.055 | 3.1 (0.72-8.3) | 6.2 (1.1-14.7) | NS | |
| IL-6 | DENV1 | 28.0 (21.2-128) | 25.1 (19.3-44.4) | 0.01 | 24.4 (19.3-1009) | 25.0 (19.9-39.6) | NS |
| DENV2 | 29.2 (13.8-124) | 30.0 (24.6-64.9) | NS | 26.8 (18.6-46.4) | 35.6 (30.8-50.4) | 0.006 | |
| IL-8 | DENV1 | 28.7 (6.7-547) | 27.2 (5.1-48.4) | NS | 26.8 (16.9-1293) | 25.5 (9.4-206) | NS |
| DENV2 | 29.7 (5.3-1535) | 36.6 (3.6-66.0) | NS | 29.9 (16.3-226) | 27.8 (9.0-40.9) | NS | |
median (minimum-maximum), significance p ≤ 0.05. Dengue virus (DENV) 1 [0-2 days: dengue fever (DF) = 26, dengue haemorrhagic fever (DHF) = 25; 3-5 days: DF = 34, DHF = 31]; DENV2 (0-2 days: DF = 25, DHF = 7; 3-5 days: DF = 16, DHF = 7). IFN: interferon; IL: interleukin; NS: nonsignificant; TNF: tumour necrosis factor.