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. 2016 Mar;111(3):218–221. doi: 10.1590/0074-02760150401

Ratio of plasma benznidazole (BNZ) concentration (mg/L)/BNZ administered dose (mg/Kg/d) during steady state phase. Patient 1 had two samples per day from three different days showed a high ratio of BNZ concentration all the times (1/1: patient 1, samples day 1; 1/2: patient 1, samples day 2; 1/3: patient 1, samples day 3). Patient 2 took half the indicated dose, her plasma drug concentration was normalised according to BNZ administered dose, and presented similar ratio as the rest of the patients of the series (patients 3, 4, 5, and 6).

Ratio of plasma benznidazole (BNZ) concentration (mg/L)/BNZ administered dose (mg/Kg/d) during steady state phase. Patient 1 had two samples per day from three different days showed a high ratio of BNZ concentration all the times (1/1: patient 1, samples day 1; 1/2: patient 1, samples day 2; 1/3: patient 1, samples day 3). Patient 2 took half the indicated dose, her plasma drug concentration was normalised according to BNZ administered dose, and presented similar ratio as the rest of the patients of the series (patients 3, 4, 5, and 6).