TABLE II. Pharmacometric parameters of patients.
| Patient ID | Time in BNZ treatment (day) | Plasma samples (times per patient) | Sampling time after last intake (hours) | Plasmatic BNZ (mg/L) | Plasmatic BNZ (mg/L)/ BNZ daily dose (mg/Kg) |
|---|---|---|---|---|---|
| 1a,b | 53 | 1/1 | 1.1 | 8.1 ± 0.1 | 3.12 |
| 1/2 | 2.7 | 12.5 ± 0.6 | 4.81 | ||
| 55 | 2/1 | 1.0 | 11.6 ± 0.3 | 4.46 | |
| 2/2 | 2.5 | 15.0 ± 0.2 | 5.77 | ||
| 60 | 3/1 | 1.1 | 11.5 ± 0.1 | 4.42 | |
| 3/2 | 3.1 | 8.2 ± 0.1 | 3.15 | ||
| 2a | 60 | 0 | 0.0 | 4.6 ± 0.1 | 1.84 |
| 1 | 1.0 | 4.9 ± 0.1 | 1.96 | ||
| 2 | 2.0 | 5.1 ± 0.1 | 2.04 | ||
| 3c | 5 | 0 | 0.0 | 5.7 ± 0.5 | 1.04 |
| 1 | 1.0 | 7.1 ± 0.1 | 1.30 | ||
| 2 | 2.0 | 6.8 ± 0.1 | 1.24 | ||
| 4c | 5 | 0 | 0.0 | 7.3 ± 0.1 | 1.77 |
| 1 | 1.0 | 8.4 ± 0.1 | 2.04 | ||
| 2 | 2.0 | 12.0 ± 0.3 | 2.91 | ||
| 5 | 17 | 0 | 0.0 | 7.5 ± 0.1 | 1.65 |
| 1 | 1.0 | 8.1 ± 0.1 | 1.78 | ||
| 2 | 2.0 | 9.7 ± 0.3 | 2.13 | ||
| 6 | 5 | 0 | 0.0 | 7.1 ± 0.1 | 1.56 |
| 1 | 1.0 | 9.4 ± 0.1 | 2.07 | ||
| 2 | 2.0 | 9.3 ± 0.1 | 2.04 |
a: patients 1 and 2 - 2.5 and 2.6 mg/kg/day dose;b: patient 1 had two samples per day from three different days; c: patients 3 and 4 - treatment was interrupted; BNZ: benznidazole.