Table 1.
Study characteristics and key results
| Report | Type of study | Study size | Clopidogrel group- (n) | Control/Non-clopidogrel group- (n) | Key results |
|---|---|---|---|---|---|
| Harty et al. 2007 [68] | Case-control (Retrospective) | 180 | 21 | 159 | Higher mortality rate in CG than NCG (p = 0.003) CG were delayed to surgery compared to NCG (7.2 vs 2.1 days, p = 0.03) |
| Johansen et al. 2008 [56] | Case-control (Retrospective) | 17 | (<5 days) 7 (>5 days) 10 |
Less drop in Hb in the CG > 5 group (p = 0.01) Thromboembolic complications in delayed group (1 death from pulmonary embolus) |
|
| Sim and Gonski 2009 [57] | Case-control (Retrospective) | 135 | 21 (<5 days) 16 (>5 days) 5 |
114 | No significant difference in all outcomes for: CG vs NCG CG < 5 vs CG > 5 |
| Cox et al 2009 [58] | Case-control (Retrospective) |
20 | (<7 days) 11 (>7 days) 9 |
Less drop in Hb in the CG >7 group (p < 0.05) | |
| Nydick et al. 2010 [53] | Case-control (Retrospective) | 50 | (23 | 27 | No significant difference in outcomes between CG and NCG |
| Chechik et al. 2011 [52] | Case-control (Prospective) | 51 | 29 | 22 | Significantly more blood loss in patients on Clopidogrel |
| Wallace et al. 2012 [63] | Case-control (Retrospective) | 110 | 52 | 58 | Statistically significant higher transfusion rates in CG (56 % CG vs 31 % NCG, p = 0.01) |
| Collinge et al. 2012 [62] | Case-control (Retrospective) | 659 | 40 | 619 | No significant difference in outcomes between CG and NCG |
| Chechik et al. 2012 [59] | Case-control (Retrospective) | 60 | (<5 days) 30 (>5 days) 30 |
No significant difference in outcomes between CG < 5 and CG >5 |
|
| Hossain et al. 2013 [61] | Case-control (Retrospective) | 102 | 50 | 52 | No significant difference in outcomes between CG and NCG |
| Feely et al. 2013 [54] | Case-control (Retrospective) | 120 | 40 | 80 | No significant difference in outcomes between CG and NCG |
| Al Khudairy et al. 2013 [60] | Case-control (Retrospective) | 47 | (<5 days) 24 (>5 days) 23 |
No significant difference in outcomes between CG < 5 and CG >5 CG > 5 had 2 pre-op cardiac complications and 4 patients died from cardiac complications. CG < 5 had 2 patients die from cardiac complications. |
|
| Wordsworth et al. 2013 [55] | Case-control (Prospective) | 1225 | 30 | 1195 | No significant difference in outcomes between CG and NCG |
| Manaqibwala et al. 2014 [64] | Case-control (Retrospective) | 162 | 15 | 147 | No significant difference in time to outcomes between CG and NCG Significantly lower preop Hb and higher ASA in CG |