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. 2016 Mar 23;4:17. doi: 10.1186/s40560-016-0146-3

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© Doi. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Possible pathway of lung injury induced by AKI. HMGB1 is a TLR4 agonist, and TLR4 induces inflammation including neutrophil activation. TLR toll-like receptor, HMGB1 high mobility group box 1