Reason for exclusion:
Not a therapeutic evaluation (n = 77)
Study ID	Reference of included citation
177	Almenawer, S. A., I. Bogza, et al. (2013). "The value of scheduled repeat cranial computed tomography after mild head injury: single-center series and meta-analysis." Neurosurgery72(1): 56–62; discussion 63–54.
335	Atlantis, E., P. Fahey, et al. (2013). "Endogenous testosterone level and testosterone supplementation therapy in chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis." BMJ Open3(8).
2050	Gans, I., K. D. Baldwin, et al. (2013). "Treatment and Management Outcomes of Tibial Eminence Fractures in Pediatric Patients: A Systematic Review." Am J Sports Med.
2062	Garces, S., J. Demengeot, et al. (2013). "The immunogenicity of anti-TNF therapy in immune-mediated inflammatory diseases: a systematic review of the literature with a meta-analysis." Ann Rheum Dis72(12): 1947–1955.
5938	Suthar, A. B., D. Hoos, et al. (2013). "Integrating antiretroviral therapy into antenatal care and maternal and child health settings: a systematic review and meta-analysis." Bull World Health Organ91(1): 46–56.
7112	Zhi, X., X. Zhou, et al. (2013). "Practical role of mutation analysis for imatinib treatment in patients with advanced gastrointestinal stromal tumors: a meta-analysis." PLoS One8(11): e79275.
475	Bauer, S. R., S. E. Hankinson, et al. (2013). "Plasma vitamin D levels, menopause, and risk of breast cancer: dose–response meta-analysis of prospective studies." Medicine (Baltimore)92(3): 123–131.
591	Bewtra, M., L. M. Kaiser, et al. (2013). "Crohn's disease and ulcerative colitis are associated with elevated standardized mortality ratios: a meta-analysis." Inflamm Bowel Dis19(3): 599–613.
597	Bhangu, A., D. Nepogodiev, et al. (2013). "Meta-analysis of plasma to red blood cell ratios and mortality in massive blood transfusions for trauma." Injury44(12): 1693–1699.
675	Bonifazi, M., I. Tramacere, et al. (2013). "Systemic sclerosis (scleroderma) and cancer risk: systematic review and meta-analysis of observational studies." Rheumatology (Oxford)52(1): 143–154.
701	Bosanquet, D. C., D. A. Harris, et al. (2013). "Systematic review and meta-analysis of intraoperative peritoneal lavage for colorectal cancer staging." Br J Surg100(7): 853–862.
717	Bougma, K., F. E. Aboud, et al. (2013). "Iodine and mental development of children 5 years old and under: a systematic review and meta-analysis." Nutrients5(4): 1384–1416.
803	Bryant, A. R., S. B. Wilton, et al. (2013). "Association between QRS duration and outcome with cardiac resynchronization therapy: a systematic review and meta-analysis." J Electrocardiol46(2): 147–155.
1017	Charidimou, A., P. Kakar, et al. (2013). "Cerebral microbleeds and recurrent stroke risk: systematic review and meta-analysis of prospective ischemic stroke and transient ischemic attack cohorts." Stroke44(4): 995–1001.
1349	Davies, A., K. P. Singh, et al. (2013). "Treatment outcomes of treatment-naive Hepatitis C patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts." PLoS One8(2): e55373.
1996	Fumery, M., C. Xiaocang, et al. (2013). "Thromboembolic events and cardiovascular mortality in inflammatory bowel diseases: A meta-analysis of observational studies." J Crohns Colitis.
2066	Garcia, S., Y. Sandoval, et al. (2013). "Outcomes after complete versus incomplete revascularization of patients with multivessel coronary artery disease: a meta-analysis of 89,883 patients enrolled in randomized clinical trials and observational studies." J Am Coll Cardiol62(16): 1421–1431.
2144	Gielen, C., O. Dekkers, et al. (2013). "The effects of pre- and postoperative fibrinogen levels on blood loss after cardiac surgery: a systematic review and meta-analysis." Interact Cardiovasc Thorac Surg.
2689	Huang, Y., R. Chen, et al. (2013). "Association between point-of-care CRP testing and antibiotic prescribing in respiratory tract infections: a systematic review and meta-analysis of primary care studies." Br J Gen Pract63(616): 787–794.
2823	James, M. T., S. M. Samuel, et al. (2013). "Contrast-induced acute kidney injury and risk of adverse clinical outcomes after coronary angiography: a systematic review and meta-analysis." Circ Cardiovasc Interv6(1): 37–43.
3014	Kaptoge, S., S. R. Seshasai, et al. (2013). "Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis." Eur Heart J.
3476	Lemos, E. V., F. P. de la Hoz, et al. (2013). "Carbapenem resistance and mortality in patients with Acinetobacter baumannii infection: systematic review and meta-analysis." Clin Microbiol Infect.
317	Arregui, M., B. Buijsse, et al. (2014). "Adiponectin and Risk of Stroke: Prospective Study and Meta-analysis." Stroke45(1): 10–17.
367	Baandrup, L., M. T. Faber, et al. (2013). "Nonsteroidal anti-inflammatory drugs and risk of ovarian cancer: systematic review and meta-analysis of observational studies." Acta Obstet Gynecol Scand92(3): 245–255.
609	Bhattacharjee, S., R. Bhattacharya, et al. (2013). "Antidepressant use and new-onset diabetes: a systematic review and meta-analysis." Diabetes Metab Res Rev29(4): 273–284.
641	Blackadar, C. B. (2013). "Systematic review of hepatocellular carcinoma mortality rates among hepatitis B virus-infected renal transplant recipients, with supplemental analyses of liver failure and all-cause mortality." Int J Infect Dis17(1): e24-36.
679	Bonovas, S., G. Nikolopoulos, et al. (2013). "Bisphosphonate use and risk of colorectal cancer: a systematic review and meta-analysis." Br J Clin Pharmacol76(3): 329–337.
707	Bosetti, C., V. Rosato, et al. (2013). "Cancer risk for patients using thiazolidinediones for type 2 diabetes: a meta-analysis." Oncologist18(2): 148–156.
771	Brinton, L. A. and A. S. Felix (2013). "Menopausal hormone therapy and risk of endometrial cancer." J Steroid Biochem Mol Biol.
1071	Chen, Y. B., Q. Chen, et al. (2013). "Insulin therapy and risk of prostate cancer: a systematic review and meta-analysis of observational studies." PLoS One8(11): e81594.
1143	Choueiri, T. K., Y. Je, et al. (2013). "Analgesic use and the risk of kidney cancer: A meta-analysis of epidemiologic studies." Int J Cancer.
2415	Hargreave, M., A. Jensen, et al. (2013). "Fertility treatment and childhood cancer risk: a systematic meta-analysis." Fertil Steril100(1): 150–161.
2443	Havrilesky, L. J., P. G. Moorman, et al. (2013). "Oral contraceptive pills as primary prevention for ovarian cancer: a systematic review and meta-analysis." Obstet Gynecol122(1): 139–147.
3024	Karlstad, O., J. Starup-Linde, et al. (2013). "Use of insulin and insulin analogs and risk of cancer - systematic review and meta-analysis of observational studies." Curr Drug Saf8(5): 333–348.
3464	Lee, S. H., R. C. Chan, et al. (2013). "Use of bisphosphonates and the risk of osteonecrosis among cancer patients: a systemic review and meta-analysis of the observational studies." Support Care Cancer.
3466	Lee, S. H., S. S. Chang, et al. (2013). "Risk of osteonecrosis in patients taking bisphosphonates for prevention of osteoporosis: a systematic review and meta-analysis." Osteoporos Int.
3933	Maneiro, J. R., E. Salgado, et al. (2013). "Immunogenicity of monoclonal antibodies against tumor necrosis factor used in chronic immune-mediated Inflammatory conditions: systematic review and meta-analysis." JAMA Intern Med173(15): 1416–1428.
4345	Namazy, J. A., V. E. Murphy, et al. (2013). "Effects of asthma severity, exacerbations and oral corticosteroids on perinatal outcomes." Eur Respir J41(5): 1082–1090.
4441	Noel, S. E., A. C. Stoneham, et al. (2013). "Consumption of omega-3 fatty acids and the risk of skin cancers: A systematic review and meta-analysis." Int J Cancer.
4695	Parsaik, A. K., B. Singh, et al. (2013). "Statins use and risk of depression: A systematic review and meta-analysis." J Affect Disord.
4923	Pradelli, D., D. Soranna, et al. (2013). "Statins and primary liver cancer: a meta-analysis of observational studies." Eur J Cancer Prev22(3): 229–234.
4971	Qi, Z. Y., C. Shao, et al. (2013). "Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis." PLoS One8(12): e83261.
4975	Qin, J., T. Yang, et al. (2013). "Oral contraceptive use and uterine leiomyoma risk: a meta-analysis based on cohort and case–control studies." Arch Gynecol Obstet288(1): 139–148.
4991	Qu, H., G. R. Sun, et al. (2013). "Clinical risk factors of delayed gastric emptying in patients after pancreaticoduodenectomy: a systematic review and meta-analysis." Eur J Surg Oncol39(3): 213–223.
5015	Rabenda, V., D. Nicolet, et al. (2013). "Relationship between use of antidepressants and risk of fractures: a meta-analysis." Osteoporos Int24(1): 121–137.
5311	Salgado, E., J. R. Maneiro, et al. (2013). "Rheumatoid factor and response to TNF antagonists in rheumatoid arthritis: Systematic review and meta-analysis of observational studies." Joint Bone Spine.
5468	Scosyrev, E., S. Tobis, et al. (2013). "Statin use and the risk of biochemical recurrence of prostate cancer after definitive local therapy: a meta-analysis of eight cohort studies." BJU Int111(3 Pt B): E71-77.
5472	Scott, I. C., R. Tan, et al. (2013). "The protective effect of alcohol on developing rheumatoid arthritis: a systematic review and meta-analysis." Rheumatology (Oxford)52(5): 856–867.
5644	Singh, I., S. Rajagopalan, et al. (2013). "Preoperative statin therapy is associated with lower requirement of renal replacement therapy in patients undergoing cardiac surgery: a meta-analysis of observational studies." Interact Cardiovasc Thorac Surg17(2): 345–352.
5646	Singh, P. P. and S. Singh (2013). "Statins are associated with reduced risk of gastric cancer: a systematic review and meta-analysis." Ann Oncol24(7): 1721–1730.
5652	Singh, S., S. K. Garg, et al. (2013). "Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett's oesophagus: a systematic review and meta-analysis." Gut.
5662	Singh, S., A. G. Singh, et al. (2013). "Statins are associated with reduced risk of esophageal cancer, particularly in patients with Barrett's esophagus: a systematic review and meta-analysis." Clin Gastroenterol Hepatol11(6): 620–629.
5674	Singh, S., P. P. Singh, et al. (2013). "Statins are associated with a reduced risk of hepatocellular cancer: a systematic review and meta-analysis." Gastroenterology144(2): 323–332.
5768	Song, Y., H. Nie, et al. (2013). "Association of statin use with risk of dementia: a meta-analysis of prospective cohort studies." Geriatr Gerontol Int13(4): 817–824.
5902	Sun, A., R. Liu, et al. (2013). "Insulin therapy and risk of colorectal cancer: an updated meta-analysis of epidemiological studies." Curr Med Res Opin.
5912	Sun, K., J. M. Liu, et al. (2013). "Bisphosphonate treatment and risk of esophageal cancer: a meta-analysis of observational studies." Osteoporos Int24(1): 279–286.
6126	Tleyjeh, I. M., A. B. Abdulhak, et al. (2013). "The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis." PLoS One8(3): e56498.
6148	Toulis, K. A., K. Hemming, et al. (2014). "beta-adrenergic receptor antagonists and fracture risk: a meta-analysis of selectivity, gender, and site-specific effects." Osteoporos Int25(1): 121–129.
6194	Tsakok, T., T. M. McKeever, et al. (2013). "Does early life exposure to antibiotics increase the risk of eczema? A systematic review." Br J Dermatol169(5): 983–991.
6196	Tsang, S. T. and P. Gaston (2013). "Adverse peri-operative outcomes following elective total hip replacement in diabetes mellitus: a systematic review and meta-analysis of cohort studies." Bone Joint J95-B(11): 1474–1479.
6245	Undela, K., K. Gudala, et al. (2013). "Statin use and risk of Parkinson's disease: a meta-analysis of observational studies." J Neurol260(1): 158–165.
6363	Varas-Lorenzo, C., N. Riera-Guardia, et al. (2013). "Myocardial infarction and individual nonsteroidal anti-inflammatory drugs meta-analysis of observational studies." Pharmacoepidemiol Drug Saf22(6): 559–570.
6427	Vis, M. M., M. A. Beijk, et al. (2013). "A systematic review and meta-analysis on primary percutaneous coronary intervention of an unprotected left main coronary artery culprit lesion in the setting of acute myocardial infarction." JACC Cardiovasc Interv6(4): 317–324.
6524	Wang, L., S. Cai, et al. (2013). "Insulin therapy contributes to the increased risk of colorectal cancer in diabetes patients: a meta-analysis." Diagn Pathol8(1): 180.
6587	Wang, Z. M., D. Zhao, et al. (2013). "Flavonol intake and the risk for stroke: A meta-analysis of cohort studies." Nutrition.
6761	Wu, Q., W. Qu, et al. (2013). "Tricyclic antidepressant use and risk of fractures: a meta-analysis of cohort and case–control studies." J Bone Miner Res28(4): 753–763.
6777	Wu, X. D., K. Zeng, et al. (2013). "Statins are associated with reduced risk of gastric cancer: a meta-analysis." Eur J Clin Pharmacol69(10): 1855–1860.
6801	Xie, Q., M. L. Chen, et al. (2013). "Isoflavone consumption and risk of breast cancer: a dose–response meta-analysis of observational studies." Asia Pac J Clin Nutr22(1): 118–127.
6817	Xing, D., X. L. Ma, et al. (2014). "Association between use of benzodiazepines and risk of fractures: a meta-analysis." Osteoporos Int25(1): 105–120.
99	Ahn, J. S., C. S. Eom, et al. (2013). "Acid suppressive drugs and gastric cancer: a meta-analysis of observational studies." World J Gastroenterol19(16): 2560–2568.
1479	Deshpande, A., V. Pasupuleti, et al. (2013). "Acid-suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis." J Gastroenterol Hepatol28(2): 235–242.
1567	Dong, J. Y., W. G. Zhang, et al. (2013). "Vitamin D intake and risk of type 1 diabetes: a meta-analysis of observational studies." Nutrients5(9): 3551–3562.
2881	Jin, G., Z. Lanlan, et al. (2014). "Pregnancy outcome following loop electrosurgical excision procedure (LEEP) a systematic review and meta-analysis." Arch Gynecol Obstet289(1): 85–99.
6972	Yuhara, H., D. A. Corley, et al. (2013). "Aspirin and non-aspirin NSAIDs increase risk of colonic diverticular bleeding: a systematic review and meta-analysis." J Gastroenterol.
3105	Khan, M. F., C. S. Wendel, et al. (2013). "Effects of percutaneous revascularization of chronic total occlusions on clinical outcomes: a meta-analysis comparing successful versus failed percutaneous intervention for chronic total occlusion." Catheter Cardiovasc Interv82(1): 95–107.
2357	Haider, B. A., I. Olofin, et al. (2013). "Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis." BMJ346: f3443.
1865	Filion, K. B., D. Chateau, et al. (2013). "Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis." Gut.
Reason for exclusion:
There is no comparison group (n = 22)
Study ID	Reference of included citation
239	Andrews, P. L., J. R. Shiber, et al. (2013). "Early application of airway pressure release ventilation may reduce mortality in high-risk trauma patients: a systematic review of observational trauma ARDS literature." J Trauma Acute Care Surg75(4): 635–641.
2186	Gomberawalla, M. M., B. S. Miller, et al. (2013). "Meta-analysis of joint preservation versus arthroplasty for the treatment of displaced 3- and 4-part fractures of the proximal humerus." Injury44(11): 1532–1539.
2214	Gopal, M., N. Padayatchi, et al. (2013). "Systematic review of clofazimine for the treatment of drug-resistant tuberculosis." Int J Tuberc Lung Dis17(8): 1001–1007.
2749	Iftikhar, I. H., E. R. Hays, et al. (2013). "Effect of oral appliances on blood pressure in obstructive sleep apnea: a systematic review and meta-analysis." J Clin Sleep Med9(2): 165–174.
3242	Koy, A., M. Hellmich, et al. (2013). "Effects of deep brain stimulation in dyskinetic cerebral palsy: a meta-analysis." Mov Disord28(5): 647–654.
3748	Lopez-Olivo, M. A., G. Pratt, et al. (2013). "Rasburicase in tumor lysis syndrome of the adult: a systematic review and meta-analysis." Am J Kidney Dis62(3): 481–492.
4255	Moulakakis, K. G., S. N. Mylonas, et al. (2013). "A systematic review and meta-analysis of hybrid aortic arch replacement." Ann Cardiothorac Surg2(3): 247–260.
4869	Pirie, D. A., B. H. Wattar, et al. (2014). "Effects of monitoring strategies on seizures in pregnant women on lamotrigine: a meta-analysis." Eur J Obstet Gynecol Reprod Biol172: 26–31.
5866	Stone, J. C., J. Clark, et al. (2013). "Estrogen and selective estrogen receptor modulators (SERMs) for the treatment of acromegaly: a meta-analysis of published observational studies." Pituitary.
998	Chang, S. J., M. Hodeib, et al. (2013). "Survival impact of complete cytoreduction to no gross residual disease for advanced-stage ovarian cancer: a meta-analysis." Gynecol Oncol130(3): 493–498.
3796	Luksic, I., S. Clay, et al. (2013). "Effectiveness of seasonal influenza vaccines in children -- a systematic review and meta-analysis." Croat Med J54(2): 135–145.
5836	Stegeman, B. H., M. de Bastos, et al. (2013). "Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis." BMJ347: f5298.
6128	Toczek, A., H. Cox, et al. (2013). "Strategies for reducing treatment default in drug-resistant tuberculosis: systematic review and meta-analysis." Int J Tuberc Lung Dis17(3): 299–307.
1681	El-Jurdi, N., T. Reljic, et al. (2013). "Efficacy of adoptive immunotherapy with donor lymphocyte infusion in relapsed lymphoid malignancies." Immunotherapy5(5): 457–466.
4169	Moawad, F. J., J. G. Cheatham, et al. (2013). "Meta-analysis: the safety and efficacy of dilation in eosinophilic oesophagitis." Aliment Pharmacol Ther38(7): 713–720.
5546	Sharma, S., C. Wu, et al. (2013). "Prevalence of complications in neuromuscular scoliosis surgery: a literature meta-analysis from the past 15 years." Eur Spine J22(6): 1230–1249.
6104	Tian, D. H., B. Wan, et al. (2013). "A systematic review and meta-analysis on the safety and efficacy of the frozen elephant trunk technique in aortic arch surgery." Ann Cardiothorac Surg2(5): 581–591.
449	Barrachina-Diez, J. M., E. Tashkandi, et al. (2013). "Long-term Outcome of One-Piece Implants. Part II: Prosthetic Outcomes. A Systematic Literature Review with Meta-Analysis." Int J Oral Maxillofac Implants28(6): 1470–1482.
2587	Hollingsworth, J. M., M. A. Rogers, et al. (2013). "Determining the noninfectious complications of indwelling urethral catheters: a systematic review and meta-analysis." Ann Intern Med159(6): 401–410.
2787	Iudici, M., S. Fasano, et al. (2013). "Prevalence and factors associated with glucocorticoids (GC) use in systemic sclerosis (SSc): a systematic review and meta-analysis of cohort studies and registries." Clin Rheumatol.i
4562	Orman, E. S., N. Li, et al. (2013). "Efficacy and durability of radiofrequency ablation for Barrett's Esophagus: systematic review and meta-analysis." Clin Gastroenterol Hepatol11(10): 1245–1255.
5702	Slater, N. J., M. van der Kolk, et al. (2013). "Biologic grafts for ventral hernia repair: a systematic review." Am J Surg205(2): 220–230.
Reason for exclusion:
Not a meta-analysis/No statistical pooling of the results (n = 16)
Study ID	Reference of included citation
175	Almekhlafi, M. A., B. K. Menon, et al. (2013). "A meta-analysis of observational intra-arterial stroke therapy studies using the Merci device, Penumbra system, and retrievable stents." AJNR Am J Neuroradiol34(1): 140–145.
1103	Chiappini, E., L. Galli, et al. (2013). "Use of combination neonatal prophylaxis for the prevention of mother-to-child transmission of HIV infection in European high-risk infants." AIDS27(6): 991–1000.
1505	Dienstknecht, T., K. Horst, et al. (2013). "A meta-analysis of operative versus nonoperative treatment in 463 scapular neck fractures." Scand J Surg102(2): 69–76.
2431	Hasan, S., L. Liu, et al. (2013). "The role of postoperative radiation and chemoradiation in merkel cell carcinoma: a systematic review of the literature." Front Oncol3: 276.
1641	Eckert, S., S. B. Freytag, et al. (2013). "Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors." Blood Press22 Suppl 1: 11–21.
960	Chacko, J., L. Harling, et al. (2013). "Can statins improve outcomes after isolated cardiac valve surgery? A systematic literature review." Clin Cardiol36(8): 448–455.
3376	Lane, D. A., S. Raichand, et al. (2013). "Combined anticoagulation and antiplatelet therapy for high-risk patients with atrial fibrillation: a systematic review." Health Technol Assess17(30): 1–188.
1926	Forman-Hoffman, V. L., A. J. Zolotor, et al. (2013). "Comparative effectiveness of interventions for children exposed to nonrelational traumatic events." Pediatrics131(3): 526–539.
141	Alcoba, G., M. Kerac, et al. (2013). "Do children with uncomplicated severe acute malnutrition need antibiotics? A systematic review and meta-analysis." PLoS One8(1): e53184.
2763	Ingargiola, M. J., L. N. Daniali, et al. (2013). "Does the application of incisional negative pressure therapy to high-risk wounds prevent surgical site complications? A systematic review." Eplasty13: e49.
3250	Krag, M., A. Perner, et al. (2013). "Stress ulcer prophylaxis in the intensive care unit: is it indicated? A topical systematic review." Acta Anaesthesiol Scand57(7): 835–847.
4889	Polk, A., M. Vaage-Nilsen, et al. (2013). "Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors." Cancer Treat Rev39(8): 974–984.
4941	Proietti, R., G. M. Manzoni, et al. (2013). "Can Cardiac Resynchronization Therapy Improve Cognitive Function? A Systematic Review." Pacing Clin Electrophysiol.
1013	Chapelle, C., S. Quenet, et al. (2013). "Antipsychotics: a real or confounding risk factor for venous thromboembolism?" Pharmacopsychiatry46(1): 36–37.
1395	de Tayrac, R. and L. Sentilhes (2013). "Complications of pelvic organ prolapse surgery and methods of prevention." Int Urogynecol J24(11): 1859–1872.
1559	Domecq, J. P., G. Prutsky, et al. (2013). "Adverse effects of the common treatments for polycystic ovary syndrome: a systematic review and meta-analysis." J Clin Endocrinol Metab98(12): 4646–4654.
Reason for exclusion:
Meta-Analysis does not include results from observational studies (n = 12)
Study ID	Reference of included citation
87	Ahmed, F., M. C. Lindley, et al. (2014). "Effect of influenza vaccination of healthcare personnel on morbidity and mortality among patients: systematic review and grading of evidence." Clin Infect Dis58(1): 50–57.
125	Albanna, A. S., B. M. Smith, et al. (2013). "Fixed-dose combination antituberculosis therapy: a systematic review and meta-analysis." Eur Respir J42(3): 721–732.
1982	Fu, R., S. Selph, et al. (2013). "Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: a systematic review and meta-analysis." Ann Intern Med158(12): 890–902.
3004	Kansagara, D., E. Dyer, et al. (2013). "Treatment of anemia in patients with heart disease: a systematic review." Ann Intern Med159(11): 746–757.
2525	Henson, C. C., S. Burden, et al. (2013). "Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy." Cochrane Database Syst Rev11: CD009896.
6034	Taylor, P. N., O. E. Okosieme, et al. (2014). "Therapy of Endocrine Disease: Impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis." Eur J Endocrinol170(1): R1-R15.
753	Bredemeier, M., F. K. de Oliveira, et al. (2013). "Low- versus high-dose rituximab for rheumatoid arthritis: A systematic review and meta-analysis." Arthritis Care Res (Hoboken).
1791	Fandino, M., K. I. Macdonald, et al. (2013). "The use of postoperative topical corticosteroids in chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis." Am J Rhinol Allergy27(5): e146-157.
3316	Kwok, C. S., V. Jeevanantham, et al. (2013). "No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: meta-analysis." Int J Cardiol167(3): 965–974.
3012	Kapadia, S., S. Hapani, et al. (2013). "Risk of liver toxicity with the angiogenesis inhibitor pazopanib in cancer patients." Acta Oncol52(6): 1202–1212.
5089	Reichenpfader, U., G. Gartlehner, et al. (2013). "Sexual Dysfunction associated with Second-Generation Antidepressants in Patients with Major Depressive Disorder: Results from a Systematic Review with Network Meta-Analysis." Drug Saf.
1936	Fortmann, S. P., B. U. Burda, et al. (2013). "Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force." Ann Intern Med.
Reason for exclusion:
Full text not available (n = 10)
Study ID	Reference of included citation
3702	Liu, Y., P. Su, et al. (2013). "Endoscopic sphincterotomy plus balloon dilation versus endoscopic sphincterotomy for choledocholithiasis: A meta-analysis." J Gastroenterol Hepatol28(6): 937–945.
3704	Liu, Y., W. Tang, et al. (2013). "Association between statin use and colorectal cancer risk: a meta-analysis of 42 studies." Cancer Causes Control.
4701	Pasipanodya, J. G. and T. Gumbo (2013). "A meta-analysis of self-administered vs directly observed therapy effect on microbiologic failure, relapse, and acquired drug resistance in tuberculosis patients." Clin Infect Dis57(1): 21–31.
5285	Saheb, K. J., B. Q. Deng, et al. (2013). "Triple antithrombotic therapy versus double antiplatelet therapy after percutaneous coronary intervention with stent implantation in patients requiring chronic oral anticoagulation: a meta-analysis." Chin Med J (Engl)126(13): 2536–2542.
5922	Sun, Z. J., W. J. Li, et al. (2013). "Comparing minimally invasive and open transforaminal lumbar interbody fusion for treatment of degenerative lumbar disease: a meta-analysis." Chin Med J (Engl)126(20): 3962–3971.
6783	Wu, Y. C., J. F. Zhang, et al. (2013). "Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis: a meta analysis." Chin Med J (Engl)126(6): 1171–1177.
7106	Zheng, Z., L. Sheng, et al. (2013). "Statins and amyotrophic lateral sclerosis: a systematic review and meta-analysis." Amyotroph Lateral Scler Frontotemporal Degener14(4): 241–245.
3598	Lin, G. H., H. L. Chan, et al. (2013). "The Effect of Flapless Surgery on Implant Survival and Marginal Bone Level: A Systematic Review and Meta-analysis." J Periodontol.
4225	More, K., G. Athalye-Jape, et al. (2013). "Association of inhibitors of gastric acid secretion and higher incidence of necrotizing enterocolitis in preterm very low-birth-weight infants." Am J Perinatol30(10): 849–856.
4175	Moen, C. A., A. Burrell, et al. (2013). "Does tranexamic acid stop haemoptysis?" Interact Cardiovasc Thorac Surg17(6): 991–994.
Reason for exclusion:
Meta-analysis not main objective (n = 6)
Study ID	Reference of included citation
1469	D'Errigo, P., F. Biancari, et al. (2013). "Thirty-day mortality after coronary artery bypass surgery in patients aged <50 years: results of a multicenter study and meta-analysis of the literature." J Card Surg28(3): 207–211.
1735	Etminan, M., S. T. Bird, et al. (2013). "Isotretinoin and risk for inflammatory bowel disease: a nested case–control study and meta-analysis of published and unpublished data." JAMA Dermatol149(2): 216–220.
1753	Faggioli, G., R. Pini, et al. (2013). "Contralateral carotid occlusion in endovascular and surgical carotid revascularization: a single centre experience with literature review and meta-analysis." Eur J Vasc Endovasc Surg46(1): 10–20.
3067	Kennedy, N. A., E. Rhatigan, et al. (2013). "A trial of mercaptopurine is a safe strategy in patients with inflammatory bowel disease intolerant to azathioprine: an observational study, systematic review and meta-analysis." Aliment Pharmacol Ther38(10): 1255–1266.
3624	Linehan, M. F., U. Nurmatov, et al. (2013). "Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis." J Allergy Clin Immunol.
4455	Nouri, K., M. Demmel, et al. (2013). "Prospective cohort study and meta-analysis of cyclic bleeding after laparoscopic supracervical hysterectomy." Int J Gynaecol Obstet122(2): 124–127.
Reason for exclusion:
No observational studies (n = 4)
Study ID	Reference of included citation
946	Cates, C. J. and B. H. Rowe (2013). "Vaccines for preventing influenza in people with asthma." Cochrane Database Syst Rev2: CD000364.
2240	Gouya, G., J. Arrich, et al. (2013). "Antiplatelet Treatment for Prevention of Cerebrovascular Events in Patients With Vascular Diseases: A Systematic Review and Meta-Analysis." Stroke.
6484	Wang, C. H., C. H. Huang, et al. (2013). "Biphasic versus monophasic defibrillation in out-of-hospital cardiac arrest: a systematic review and meta-analysis." Am J Emerg Med31(10): 1472–1478.
4859	Pineda, A. M., F. O. Nascimento, et al. (2013). "A meta-analysis of transcatheter closure of patent foramen ovale versus medical therapy for prevention of recurrent thromboembolic events in patients with cryptogenic cerebrovascular events." Catheter Cardiovasc Interv.
Reason for exclusion:
Not published in 2013 (n = 4)
Study ID	Reference of included citation
179	Almenawer, S. A., F. Farrokhyar, et al. (2013). "Chronic Subdural Hematoma Management: A Systematic Review and Meta-analysis of 34829 Patients." Ann Surg.
3159	Klatte, T., S. F. Shariat, et al. (2013). "Systematic review and meta-analysis of perioperative and oncological outcomes of laparoscopic cryoablation versus laparoscopic partial nephrectomy for the treatment of small renal tumors." J Urol.
5708	Sligl, W. I., L. Asadi, et al. (2013). "Macrolides and Mortality in Critically Ill Patients With Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis." Crit Care Med.
6482	Wang, C. H., W. H. Hsieh, et al. (2013). "Liberal Versus Restricted Fluid Resuscitation Strategies in Trauma Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies." Crit Care Med.
Reason for exclusion:
Individual Patient Data meta-analysis (n = 2)
Study ID	Reference of included citation
5616	Simmonds, M. C., J. V. Brown, et al. (2013). "Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data." Ann Intern Med158(12): 877–889.
485	Bazelier, M. T., F. de Vries, et al. (2013). "Risk of fracture with thiazolidinediones: an individual patient data meta-analysis." Front Endocrinol (Lausanne)4: 11.