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HE and Masson staining in the normal (left) and stretched (right) MV demonstrating increased leaflet thickness and spongiosa matrix after 2 months of stretching in a sheep model. Blue indicates collagen. Abbreviations: HE, hematoxylin and eosin; MV, mitral valve; S, spongiosa. Reprinted from Dal-Bianco, J. P. et al. Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation. Circulation 120 (4), 334–342 (2009).
