. Author manuscript; available in PMC: 2016 Mar 23.

Published in final edited form as: Nat Rev Cardiol. 2015 Oct 20;12(12):689–710. doi: 10.1038/nrcardio.2015.161

Table 1.

Echocardiographic differences between so-called Barlow disease and fibroelastic deficiency⁴⁴

Lesion	Barlow disease	Fibroelastic deficiency
Primary effects	Excess valve tissue	No excess valve tissue
	Posterior leaflet height >annulus septal–lateral diameter^*	Excess tissue and thickness if present limited to the prolapsing segment
	Anterior leaflet height >38 mm^*	Thin leaflets in nonprolapsing segments
	Leaflet thickness >3 mm	No leaflet billowing
	Leaflet billowing	Prolapse often limited to one scallop (usually P2)^*
	Prolapse of multiple scallops^*	Elongated chordae
	Atrialization of the base of the posterior leaflet^* Chordae thickened, elongated, and calcified Chordal rupture infrequent	Chordal rupture^*

Secondary effects	Leaflet or annular calcifications^* Constant annular dilatation involving preferentially the posterior region	No calcifications^* Inconsistent or only moderate annular dilatation

Inconsistent, but frequent lesions.