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. Author manuscript; available in PMC: 2017 Mar 5.
Published in final edited form as: Eur J Pharmacol. 2016 Feb 3;774:25–33. doi: 10.1016/j.ejphar.2016.01.007

Fig 3. Enzyme specific substrates for ACE and ACE2 activity assays.

Fig 3

ACE- and ACE2-specific substrates were completely hydrolyzed by (A) rhACE2 and (C) rhACE, respectively (n=6). (B) ACE-specific substrate was not hydrolyzed by rhACE2 (n=4), and along the similar lines, (D) ACE2-specific substrate was not hydrolyzed by rhACE (n=4). (E-G) ACE versus ACE2 selectivity of MLN-4760 in recombinant human enzymes (n=6). Racemic mixture and the isomers were denoted as MLN-4760-R, MLN-4760-A and MLN-4760-B.