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ACE versus ACE2 selectivity of MLN-4760, (A) racemic mixture, (B) isomer A and (C) isomer B, in human mononuclear cells (n=6). (D) ACE2 activity, and ACE versus ACE2 selectivity of the isomer B of MLN-4760 in human CD34+ cells (n=6). Racemic mixture and the isomers were denoted as MLN-4760-R, MLN-4760-A and MLN-4760-B.
