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ACE versus ACE2 selectivity of MLN-4760, racemic mixture, and isomers A and B, in murine heart (A-C), and in murine mononuclear cells (D-F) (n=6). (G) ACE2 activity, and ACE versus ACE2 selectivity of the isomer B of MLN-4760 in murine Lin- cells (n=5). Racemic mixture and the isomers were denoted as MLN-4760-R, MLN-4760-A and MLN-4760-B.
