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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: J Pharm Sci. 2015 Sep 28;104(12):4056–4064. doi: 10.1002/jps.24654

Figure 2.

Figure 2

Particle concentrations measured in 3M formulations as a function of the polysorbate 20:3M molar ratio in the formulation. Open symbols represent the particle concentrations in 3M formulations that were not incubated. Closed symbols represent the particle concentrations in 3M formulations that were agitated for 24 hours with an air bubble in siliconized syringes. The color of each symbol corresponds to the polysorbate 20 concentration (% v/v) in the formulation: 0% (black), 0.0005% (red), 0.001% (green), 0.002% (blue), 0.005% (gray), 0.01% (pink). At each polysorbate 20:3M ratio, the particle concentration in a buffer solution with the same polysorbate 20 concentration was subtracted from the particle concentration measured in the non-incubated 3M formulation and from that measured in the agitated 3M formulation.