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. 2016 Mar 23;7:33. doi: 10.3389/fgene.2016.00033

Figure 4.

Figure 4

(A) Expression of AP-1 factor genes. In orange FOS TF genes are shown, and in blue JUN TF genes. At early stages the expression levels of FOS and JUN genes which are AP-1 components is rather limited. It is likely that AP-1 cannot be formed due to the low expression of FOS genes. In later stages (> day 13), AP-1 and especially FOS increases its expression. (B) Expression of TF genes which contain a POU-domain, in blue (POU5F1) and orange (POU2F1) are the two genes which are above the threshold. POU5F1 which is more abundant than POU2F1 decreases during the time course and was absent after day 13. (C) Expression of GATA genes, in blue (GATA6) and orange (GATA4) are above the threshold. GATA6 is expressed during the mesoderm induction stage and decreases afterwards, while GATA4 becomes supreme in subsequent stages. The red lines show a FPKM value of 10 that we consider as threshold for sufficiently expressed genes which contribute to regulatory effects.