Figure 1.

An illustration of the treatment schedule and timing of tissue harvesting is shown for tissue samples used in the construction of the TMA. Animals were inoculated with tumor cells at seven days prior to treatment initiation. Animals were dosed daily for seven days at times 0, 24, 48, 72, 96, 120, and 144 hr (solid arrows). Tumor tissue was harvested (dashed arrows) at 2, 4, 6 and 24 hr after the first treatment, and 6 hr after treatment on days 3 and 5. The last tumor harvest was performed at 24 hr following the final treatment (168 hr).