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CYP2C6 (A) and CYP2C11 enzyme activities (B) in rat hepatic microsomes. CYP2C6 was measured as diclofenac 4′-hydroxylation (nmol 4′-hydroxydiclofenac/min × mg protein) and CYP2C11 as testosterone 16α-hydroxylation (nmol 16α-hydroxytestosterone/min × mg protein). All values are given as the means ± SD (n = 3). Numbers above columns (“F”) indicate fold changes in enzyme activities compared to control. Comparison was performed by t-test analysis; ***P < 0.001, different from control.
