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Effect of Dexmedetomedine (DEX) on the recovery of L-type calcium current (ICa-L) from inactivation. The pulse was composed of two pulses, one 300 ms prepulse from -50 mV to +10 mV, followed by a repolarizing pulse to -50 mV which progressively prolonged durations from 50 to 500 ms with 50 in 50 ms increment, and then a 200 ms test pulse to +10 mV. DEX (0.6, 1.8, 5.4, 10 and 200 ng/ml) shifted the curve to the right. (n = 6, *p < 0.05)
