Figure 1.

Effects of sitagliptin on the spontaneous beating rate of pulmonary vein (PV) and right atrium (RA) in Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). An example and average data (n = 7) show that the WKY and SHR PVs had slower spontaneous beating rate than WKY and SHR RA, respectively (p < 0.05). The treatment of sitagliptin did not significantly change the PV or RA beating rates of WKY and SHR, but has the trend to increase the automaticity of PV. Thus, the spontaneous beating rates of PV are no longer significantly different from that of RA in WKY and SHR with the treatment of sitagliptin.