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. 1963 Jan;16(1):61–64. doi: 10.1136/jcp.16.1.61

Hepatic and cardiac necrosis in a patient with prostatic carcinoma given ε-aminocaproic acid

F Nour-Eldin 1, T F Draisey 1
PMCID: PMC480487  PMID: 13939069

Abstract

The pathological findings in a case of prostatic carcinoma with fibrinolysin, treated with ε-aminocaproic acid, included hepatic and cardiac necrosis. The possibility is discussed that the latter lesions may be a complication of ε-aminocaproic acid therapy or produced by the proteolytic action of the fibrinolysin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASTRUP T. The biological significance of fibrinolysis. Lancet. 1956 Sep 15;271(6942):565–568. doi: 10.1016/s0140-6736(56)92048-7. [DOI] [PubMed] [Google Scholar]
  2. BERALDO W. T. Formation of bradykinin in anaphylactic and peptone shock. Am J Physiol. 1950 Nov;163(2):283–289. doi: 10.1152/ajplegacy.1950.163.2.283. [DOI] [PubMed] [Google Scholar]
  3. CLIFFTON E. E. The use of plasmin in the treatment of intravascular thromboses. J Am Geriatr Soc. 1958 Feb;6(2):118–127. doi: 10.1111/j.1532-5415.1958.tb00694.x. [DOI] [PubMed] [Google Scholar]
  4. COSGRIFF S. W., LEIFER E. Factor 5 deficiency in hemorrhagic diathesis (parahemophilia). J Am Med Assoc. 1952 Feb 9;148(6):462–463. doi: 10.1001/jama.1952.62930060003012b. [DOI] [PubMed] [Google Scholar]
  5. NILSSON I. M., BJORKMAN S. E., ANDERSSON L. Clinical experiences with 6-aminocaproic acid (6-ACA) as an antifibrinolytic agent. Acta Med Scand. 1961 Oct;170:487–509. doi: 10.1111/j.0954-6820.1961.tb00264.x. [DOI] [PubMed] [Google Scholar]
  6. NILSSON I. M., SJOERDSMA A., WALDENSTROM J. Antifibrinolytic activity and metabolism of 6-aminocaproic acid in man. Lancet. 1960 Jun 18;1(7138):1322–1326. doi: 10.1016/s0140-6736(60)92305-9. [DOI] [PubMed] [Google Scholar]
  7. SHERRY S., FLETCHER A. P., ALKJAERSIG N. Fibrinolysis and fibrinolytic activity in man. Physiol Rev. 1959 Apr;39(2):343–382. doi: 10.1152/physrev.1959.39.2.343. [DOI] [PubMed] [Google Scholar]
  8. STEFANINI M. Activity of plasma labile factor in disease. Lancet. 1951 Mar 17;1(6655):606–610. doi: 10.1016/s0140-6736(51)91115-4. [DOI] [PubMed] [Google Scholar]

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