Table 1. Baseline characteristics of study population with and without preexisting clinical evidence of cardiovascular disease .
| Parameter | All patients N = 140 | CVD n = 61 | Non-CVD n = 79 | p value |
| Age (yr) | 61.0 ± 12.4 | 64.0 ± 10.4 | 58.7 ± 13.4 | 0.01 |
| Male gender (%) | 53 (38%) | 27 (44%) | 26 (33%) | 0.17 |
| Duration of dialysis (yr) | 6.7 ± 3.5 | 7.6 ± 3.8 | 6.1 ± 3.2 | 0.01 |
| Hypertension (%) | 78 (56%) | 43 (70%) | 35 (44%) | 0.002 |
| Diabetes mellitus (%) | 69 (49%) | 40 (66%) | 29 (37%) | < 0.001 |
| Hyperlipidemia (%) | 53 (38%) | 26 (49%) | 23 (31%) | 0.04 |
| Smoker (%) | 24 (17%) | 15 (25%) | 9 (12%) | 0.04 |
| Medications (%) | ||||
| Statins | 17 (12%) | 8 (13%) | 9 (11%) | 0.76 |
| Beta-blockers | 28 (20%) | 15 (25%) | 13 (16%) | 0.23 |
| ACEi/ARBs | 30 (21%) | 17 (28%) | 13 (16%) | 0.10 |
| Aspirin | 47 (34%) | 30 (49%) | 17 (22%) | < 0.001 |
| Cilostazol | 20 (14%) | 13 (21%) | 7 (9%) | 0.04 |
| BUN (mg/dl) | 64.3 ± 19.8 | 66.4 ± 17.3 | 62.7 ± 21.5 | 0.27 |
| Creatinine (mg/dl) | 10.7 ± 2.6 | 10.4 ± 2.1 | 11.0 ± 2.8 | 0.14 |
| Albumin (g/dl) | 3.87 ± 0.35 | 3.83 ± 0.28 | 3.91 ± 0.39 | 0.19 |
| Hemoglobin (g/dl) | 9.9 ± 1.2 | 9.8 ± 1.2 | 9.9 ± 1.1 | 0.67 |
| Fasting glucose (mg/dl) | 148 ± 70 | 168 ± 81 | 133 ± 56 | 0.003 |
| Hemoglobin A1c (%) | 7.3 ± 1.5 | 7.9 ± 1.7 | 6.8 ± 1.4 | 0.01 |
| Total cholesterol (mg/dl) | 187 ± 40 | 192 ± 41 | 183 ± 40 | 0.20 |
| LDL-C (mg/dl) | 120 ± 30 | 123 ± 34 | 118 ± 27 | 0.38 |
| Intact PTH (pg/ml) | 301 ± 298 | 247 ± 292 | 332 ± 342 | 0.07 |
| LVEF | 0.60 ± 0.14 | 0.55 ± 0.14 | 0.64 ± 0.11 | 0.01 |
| Ankle-brachial index | 0.93 ± 0.22 | 0.84 ± 0.26 | 0.99 ± 0.16 | < 0.001 |
| hsCRP (mg/dl) | 2.34 ± 1.96 | 2.77 ± 2.02 | 2.05 ± 1.87 | 0.04 |
| Thrombospondin-1 (ug/ml) | 4.25 ± 2.74 | 5.41 ± 3.41 | 3.35 ± 1.61 | < 0.001 |
ACEi/ARBs, angiotensin-converting enzyme inhibitor/angiotensin receptor blockers; BUN, blood urea nitrogen; CVD, cardiovascular disease; hsCRP, high sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; LVEF, left ventricular ejection fraction; PTH, parathyroid hormone.