Figure 1. Passive permeability changes in brain metastases in the 4T1-BR5 model.
The relative 14C-AIB permeability fold-change in relation to metastasis size (mm2) revealed little correlation (r2=0.23) (a). The permeability fold-change of Texas Red dextran compared to metastasis size (mm2) did not correlate (r2=0.069) (b). A representative brain slice (approximately 0.86mm rostral to Bregma) bearing 4T1-BR5 metastases (c; cresyl violet) and its corresponding TRD fluorescence (d) and 14C-AIB autoradiograph (e).