Table 3. Comparisons of absolute values and (% change) of pharmacodynamic parameters 20 mins after IV infusion 2 mg of levosimendan between Chinese and Caucasian subjects .
| Parameters | This study (n = 14) | Orion report23 (n = 8) |
| Dose & route | 2 mg, IV infusion | 2 mg, IV infusion |
| HR (beat/min) | 75 ± 13 (+14.3 ± 11.2%)* | 58 ± 8 (+10.1 ± 14.2%) |
| sBP (mmHg) | 117 ± 12 (+7.0 ± 11.1%) | 115 ± 8 (+3.5 ± 7.0%) |
| dBP (mmHg) | 63 ± 6 (+0.9 ± 18.6%) | 48 ± 8 (-0.16 ± 11.0%) |
| LVESD (mm) | 27 ± 4 (-13.3 ± 8.9%) | 33 ± 3 (-12.9 ± 3.2%) |
| LVEDD (mm) | 45 ± 3 (-4.4 ± 5.8%) | 53 ± 4 (-0.8 ± 4.3%) |
| EF (%) | 70 ± 8 (+12.2 ± 11.4%)# | 67 ± 4 (+22.7 ± 7.0%) |
| CO (L/min) | 4.8 ± 0.6 (+15.6 ± 18.0%) | 5.1 ± 0.3 (+32.2 ± 26.1%) |
CO, cardiac output; dBP, diastolic blood pressure; EF, ejection fraction; HR, heart rate; sBP, systolic blood pressure; LVEDD, left ventricle end diastolic dimension; LVESD, left ventricle end systolic dimension; IV, intravenous; 23, Orion Pharmaceutica, Report No. 300101, 1993.
* Percent changes between -10 and 20 min after IV infusion were shown in brackets; # p < 0.05 when % Change after IV infusion comparison between Chinese and Caucasian subjects with ANOVA test.