Table 2.
Trait | Basic Adjustmenta |
Additional Adjustmentb |
||||
---|---|---|---|---|---|---|
Difference | 95% CI | P Value | Difference | 95% CI | P Value | |
African ancestry | ||||||
Free cotinine, nmol/mLc | 0.057 | 0.021, 0.094 | 0.0023 | 0.076 | 0.037, 0.12 | 1.8 × 10−4 |
Free cotinine among C-oxidation productsd | 0.11 | 0.037, 0.19 | 0.004 | 0.13 | 0.053, 0.21 | 0.0012 |
% cotinine glucuronidatione | −7.4 | −10.6, −4.1 | 1.3 × 10−5 | −8.6 | −12.1, −5.0 | 4.5 × 10−6 |
% cotinine glucuronidation among C-oxidation productsf | −2.5 | −4.2, −0.9 | 0.003 | −3.1 | −4.9, −1.3 | 0.0011 |
Asian ancestry | ||||||
Free cotinine, nmol/mLc | 0.033 | 0.015, 0.052 | 0.0004 | 0.033 | 0.014, 0.052 | 8.8 × 10−4 |
Free cotinine among C-oxidation productsd | 0.08 | 0.04, 0.12 | 1.3 × 10−4 | 0.080 | 0.034, 0.12 | 5.0 × 10−4 |
Abbreviation: CI, confidence interval.
a Basic adjustment for age at urine collection, sex, creatinine (log transformed), total nicotine equivalents (log transformed), and self-reported numbers of cigarettes smoked per day during the last 2 weeks before urine collection.
b Additional adjustment for body mass index, physical activity, ethanol drinking, caffeine intake, and education.
c Differences shown are for cube root-transformed values.
d Differences shown are for log[free cotinine/(total cotinine + total trans-3′-hydroxycotinine)].
e Calculated as [cotinine-glucuronide/total cotinine].
f Calculated as [cotinine-glucuronide/(total cotinine + total trans-3′-hydroxycotinine)].