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. 2016 Mar 7;13(4):3466–3474. doi: 10.3892/mmr.2016.4986

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Constitutive expression of Wnt/β-catenin signaling in liver cancer SP cells. (A) TOPflash and FOPflash assay indicating that β-catenin is markedly upregulated in liver cancer SP cells. (B) Western blot image indicating the increased β-catenin protein expression in SP cells. (C) Reverse transcription-quantitative polymerase chain reaction analysis indicating the increased mRNA expression of Wnt/β-catenin target genes in SP cells. SP, side-population; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; AXIN2, axis inhibition protein 2; CCND1, cyclin D1; DKK1, dickkopf Wnt signaling pathway inhibitor 1. ^*P<0.05 and ^**P<0.01 vs. non-SP cells.