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. 2015 Nov 25;139(2):431–443. doi: 10.1093/brain/awv325

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© The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effect of 4-ethyloctanoic acid on AMPA (GluA2/A3) mediated current in Xenopus oocytes induced by L-glutamate. (A) Representative trace recording showing the effect of 4-ethyloctanoic acid at indicated concentrations on AMPA (GluA2/A3) current following application of glutamate (100 µM). (B) Inhibitory dose-response curves of 4-ethyloctanoic acid (n = 4) in the presence of glutamate (100 μM), with data present as means ± SEM. The responses are normalized to the maximal current response induced by application of L-glutamate for each recording.