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. 2016 Jan 27;139(2):616–630. doi: 10.1093/brain/awv351

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© The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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The anatomy of the limbic tracts in relation to childhood ASD symptoms. (A) Tractography reconstructions of the limbic pathways. (B) Negative correlation between the number of streamlines of the left uncinate fasciculus and the total A4 score for impaired socioemotional reciprocity in the ADI-R (Pearson’s correlation = −0.295; P = 0.01) in the ASD group. ASD participants with a (C) significant history of impaired use of facial expression in childhood and (D and E) late use of first single words had a significantly lower fractional anisotropy (FA) and higher radial diffusivity in the left uncinate fasciculus.