Figure 4.

YM155 decreases the expression levels of K_v1.5 and K_v2.1 in hypoxic human pulmonary artery smooth muscle cells. Expression levels were determined using (A) reverse transcription-polymerase chain reaction and (B) Western blot analyses. Data are presented as the mean ± standard deviation (n=3). ^*P<0.05 vs. N group; ^**P<0.05 vs. H group. YM155, sepantronium bromide; N, normoxia; H, hypoxia; NY, normoxia + 100 nmol/l YM155; HY1, hypoxia + 1 nmol/l YM155; HY10, hypoxia + 10 nM YM155; HY100, hypoxia + 100 nmol/l YM155; K_v, K⁺ voltage-dependent channel.