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. 2016 Feb 15;13(4):2981–2990. doi: 10.3892/mmr.2016.4891

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Copyright: © Choi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Treadmill exercise promotes mature BDNF expression. (A) Representative photomicrographs of western blot analysis showing BDNF levels in the hippocampus of rats in the SC, SC+EX, 2VO and 2VO+EX groups. (B) The intensity of each band was densitometrically determined and normalized against β-actin. Results are presented as the mean ± standard error of the mean, n=4. ^**P<0.01, ^***P<0.001 vs. SC; ^#P<0.05 vs. 2VO. SC, sham-surgery group; SC+EX, sham-surgery group subjected to treadmill exercise (15 m/min, 30 min/day for 4 weeks); 2VO, 2VO surgery group; 2VO+EX, 2VO-surgery group subjected to treadmill exercise (15 m/min, 30 min/day for 4 weeks); BDNF, brain-derived neurotrophic factor.