Table 1. Mixed-effects regression modeling, change in coagulation parameters per 100ng/mL aPC.
| Parameter | Coefficient* | 95% CI | p |
|---|---|---|---|
| Clotting Time (seconds) | 25.75 | 22.50–28.99 | <0.001 |
| Clot Formation Time (seconds) | 16.17 | 13.10–19.24 | <0.001 |
| Alpha angle (degrees) | -1.45 | -1.31–-1.60 | <0.001 |
| Clot strength at 10 min (mm) | -1.11 | -0.99–1.22 | <0.001 |
| Clot strength at 20 min (mm) | -0.84 | -0.74–-0.95 | <0.001 |
| Maximum Clot Formation (mm) | -0.65 | -0.56–-0.73 | <0.001 |
| Maximum Lysis (%) | -0.24 | -0.20–-0.29 | <0.001 |
| PT (seconds) | 0.07 | 0.06–0.08 | <0.001 |
| PTT (seconds) | 1.92 | 1.66–2.17 | <0.001 |
| Factor V (% activity) | -0.95 | -0.81–-1.09 | <0.001 |
| Factor VIII (% activity) | -2.18 | -1.73–-2.62 | <0.001 |
* Coefficients represent change in parameter for every 100ng/mL aPC, as determined by mixed effect regression modeling, clustered by subject; mm, millimeters.