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Transgene expression in DM1 mouse skeletal muscle. Expression of Acta1, Dmpk and transgenes was determined in GPS muscle of each DM1 mouse model. Transcripts were quantified by northern blotting using 18S rRNA for normalization (n ≥ 4). Endogenous Dmpk RNA levels in DM500 GPS muscle were used as reference (set to one). Mean + SEM are shown. a.u., arbitrary units; n.d., not determined (Dmpk and transgenic signals overlap); n.a., not applicable.
