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In this CALI-based strategy, Ru(II)(tris-bipyridyl)2+ (purple motif, inset) functions as a photosensitizer for the generation of singlet oxygen (1O2). Binding of the peptoid (inset, blue motif) to a specific POI (e.g., VEGFR, 26S proteasome) allows targeted inactivation of POI by excess 1O2 produced by the Ru catalyst upon irradiation with the visible light of indicated parameters.
