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SyAMs. The tethered bifunctional SyAMs unite disease-relevant targets (cancer cells/viral and bacteria pathogens) and immune cells by binding simultaneously to a specific membrane antigen and Fc gamma receptor I. This prompts immune clearance of the targets. Inset, the third-generation SyAM-P3 comprising a pair of CP33, the FcgRI binding motif, and a pair of prostate-specific antigen binding motifs.
