Table 4.
Predictive characteristics of different cut-points of venous lactate for the composite neonatal outcome (N=7741)
| Venous lactate cut-point (mmol/L) | Sensitivity (95% CI) |
Specificity (95% CI) |
Positive Predictive Value (95% CI) |
Negative Predictive Value (95% CI) |
Positive Likelihood Ratio (95% CI) |
Negative Likelihood Ratio (95% CI) |
|---|---|---|---|---|---|---|
|
3.4 (‘optimal’ cut-point in cohort) |
75.0 (65.6, 83.0) |
69.7 (68.6, 70.7) |
3.3 (2.6, 4.1) |
99.5 (99.3, 99.7) |
2.5 (2.2, 2.8) |
0.4 (0.3, 0.5) |
|
4.4 (based on arterial cut-point of 4.8 [23]) |
53.8 (43.8, 63.7) |
86.3 (85.5, 87.1) |
5.1 (3.9, 6.6) |
99.3 (99.0, 99.5) |
3.9 (3.3, 4.7) |
0.5 (0.4, 0.7) |
|
5.6 (based on arterial cut-point of 6.0 [2]) |
36.5 (27.3, 46.6) |
94.8 (94.3, 95.3) |
8.7 (6.2, 11.8) |
99.1 (98.8, 99.3) |
7.0 (5.4, 9.2) |
0.7 (0.6, 0.8) |
|
5.7 (95th percentile in cohort) |
35.6 (26.4, 45.6) |
95.2 (94.7, 95.6) |
9.1 (6.5, 12.3) |
99.1 (98.8, 99.3) |
7.4 (5.6, 9.7) |
0.7 (0.6, 0.8) |
|
8.0 (99th percentile in cohort) |
18.3 (11.4, 27.1) |
99.2 (98.9, 99.4) |
23.2 (11.6, 33.8) |
98.9 (98.6, 99.5) |
22.1 (13.8, 35.6) |
0.8 (0.7, 0.9) |