Table 2. Associations of fractional anisotropy in selected tracts with lap time variation for all three groups.
| Young (aged 26 to 50) N=51 |
Young-old (aged 50-70) N=209 |
Old-old (aged 70-96) N=233 |
|
|---|---|---|---|
| Model 1: adjusted for age, sex, height, and weight | |||
| Cortico-cortical tracts | |||
| Superior longitudinal fasciculus |
−0.031 (−0.183, 0.121) 0.681 |
−0.019 (−0.086, 0.048) 0.576 |
0.036 (−0.010, 0.082) 0.125 |
| Inferior fronto- occipital fasciculus |
0.045 (−0.079, 0.168) 0.472 |
−0.036 (−0.103, 0.031) 0.291 |
−0.007 (−0.061, 0.047) 0.794 |
| Uncinate fasciculus | −0.058 (−0.172, 0.056) 0.311 |
−0.029 (−0.086, 0.028) 0.314 |
0.012 (−0.040, 0.064) 0.650 |
| Interhemispheric tract | |||
| Genu of corpus callosum |
0.091 (−0.075, 0.257) 0.276 |
0.004 (−0.070, 0.078) 0.908 |
−0.016 (−0.070, 0.038) 0.560 |
| Body of corpus callosum |
−0.024 (−0.188, 0.139) 0.765 |
−0.089 (−0.159, −0.019) 0.013 |
0.007 (−0.043, 0.057) 0.782 |
| Splenium of corpus callosum |
−0.016 (−0.200, 0.168) 0.862 |
−0.082 (−0.167, 0.002) 0.055 |
−0.009 (−0.052, 0.034) 0.669 |
| Subcortical tracts | |||
| Anterior limb of the internal capsule |
0.011 (−0.156, 0.178) 0.894 |
0.017 (−0.053, 0.087) 0.637 |
0.008 (−0.042, 0.058) 0.757 |
| Anterior corona radiata |
0.047 (−0.108, 0.202) 0.545 |
−0.010 (−0.083, 0.064) 0.796 |
0.014 (−0.049, 0.077) 0.663 |
|
| |||
|
Model 2: model 1 + macrostructural white matter damage
| |||
| Cortico-cortical tracts | |||
| Superior longitudinal fasciculus |
−0.035 (−0.190, 0.120) 0.653 |
−0.013 (−0.083, 0.056) 0.706 |
0.036 (−0.014, 0.086) 0.162 |
| Inferior fronto- occipital fasciculus |
0.050 (−0.078, 0.178) 0.433 |
−0.032 (−0.101, 0.036) 0.352 |
−0.008 (−0.063, 0.047) 0.779 |
| Uncinate fasciculus | −0.057 (−0.173, 0.059) 0.329 |
−0.027 (−0.085, 0.032) 0.369 |
0.009 (−0.044, 0.063) 0.732 |
| Interhemispheric tract | |||
| Genu of corpus callosum |
0.090 (−0.082, 0.262) 0.296 |
0.014 (−0.063, 0.092) 0.713 |
−0.016 (−0.072, 0.040) 0.580 |
| Body of corpus callosum |
−0.031 (−0.202, 0.139) 0.711 |
−0.094 (−0.172, −0.016) 0.019 |
0.005 (−0.049, 0.059) 0.845 |
| Splenium of corpus callosum |
−0.032 (−0.237, 0.174) 0.755 |
−0.089 (−0.190, 0.012) 0.084 |
−0.014 (−0.061, 0.034) 0.571 |
| Subcortical tracts | |||
| Anterior limb of the internal capsule |
0.015 (−0.156, 0.186) 0.860 |
0.020 (−0.051, 0.091) 0.581 |
0.006 (−0.047, 0.058) 0.837 |
| Anterior corona radiata |
0.045 (−0.114, 0.204) 0.574 |
0.000 (−0.083, 0.083) 0.996 |
0.010 (−0.063, 0.084) 0.783 |
|
| |||
|
Model 3: model 1 + mean lap time
| |||
| Cortico-cortical tracts | |||
| Superior longitudinal fasciculus |
−0.031 (−0.185, 0.123) 0.686 |
−0.002 (−0.070, 0.066) 0.957 |
0.041 (−0.001, 0.084) 0.058 |
| Inferior fronto- occipital fasciculus |
0.046 (−0.081, 0.172) 0.469 |
−0.022 (−0.090, 0.046) 0.523 |
0.008 (−0.042, 0.059) 0.740 |
| Uncinate fasciculus | −0.060 (−0.177, 0.058) 0.311 |
−0.018 (−0.076, 0.039) 0.533 |
0.025 (−0.023, 0.073) 0.311 |
| Interhemispheric tract | |||
| Genu of corpus callosum |
0.091 (−0.077, 0.259) 0.282 |
0.013 (−0.061, 0.086) 0.737 |
0.001 (−0.049, 0.052) 0.967 |
| Body of corpus callosum |
−0.024 (−0.191, 0.142) 0.769 |
−0.075 (−0.146, −0.003) 0.040 |
0.025 (−0.022, 0.071) 0.298 |
| Splenium of corpus callosum |
−0.016 (−0.204, 0.173) 0.867 |
−0.072 (−0.156, 0.013) 0.095 |
0.003 (−0.037, 0.043) 0.886 |
| Subcortical tracts | |||
| Anterior limb of the internal capsule |
0.011 (−0.158, 0.180) 0.895 |
0.030 (−0.040, 0.100) 0.403 |
0.019 (−0.028, 0.065) 0.427 |
| Anterior corona radiata |
0.047 (−0.110, 0.205) 0.547 |
0.007 (−0.068, 0.081) 0.860 |
0.034 (−0.025, 0.092) 0.255 |
Note: Fractional anisotropy was in a standardized unit. Values of lap time variation was log transformed due to its skewed distribution.