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. Author manuscript; available in PMC: 2016 Mar 23.
Published in final edited form as: Cell Rep. 2016 Mar 10;14(11):2587–2598. doi: 10.1016/j.celrep.2016.02.045

Figure 4. RBBP4 regulates H3K9Ac and binds MGMT and RAD51 promoters in complex with p300.

Figure 4

(A) ChIP evaluating the H3K9Ac and H3K9me3 levels within MGMT promoter region comparing T98G-shNT versus T98G-shRBBP4 cells. (B) ChIP evaluating recruitment of SP1, C-JUN, NF-kB (p65) and H3K9Ac to bind MGMT promoter region comparing T98G-shNT versus T98G-shRBBP4 cells. (C) ChIP assessing the recruitment of E2F1 to the RAD51 promoter in T98G-shNT compared with the T98G-shRBBP4. (D) ChIP evaluating RBBP4 and p300 recruitment to the MGMT promoter in T98G-shNT comparing with T98G-RBBP4 cells. (E) RBBP4 and p300 ChIP re-ChIP depicting co-occupancy of RBBP4 within the MGMT promoter region and (F) the RAD51 promoter.