Table 3.
Replication in TRIBE.
| Study Information | Reported AUC (95% CI) | AUC in TRIBE (95% CI) | |||||
|---|---|---|---|---|---|---|---|
| First Author, Year | Provided Combination | Biomarkers | Apparent | Center-Adjusted | Optimism-Corrected | Center-Adjusted and Optimism-Corrected | |
| de Geus, 2011 | No | uNGAL, pNGAL at admission | 0.83 (0.75–0.91) | 0.665 (0.585, 0.739) | 0.655 (0.573, 0.736) | 0.663 (0.583, 0.737) | 0.647 (0.565, 0.728) |
|
| |||||||
| Kokkoris, 2012 | Yes | pNGAL, sCr at admission | 0.823 (0.73–0.89) | 0.702 (0.655, 0.745) | 0.691 (0.647, 0.733)¥ | ||
| pNGAL, uNGAL, sCr at admission | 0.835 (0.75–0.90) | 0.704 (0.660, 0.746)¥ | 0.690 (0.649, 0.733)¥ | ||||
|
| |||||||
| Cho, 2013 | No | uNGAL, uLFABP at admission | 0.800 (0.727–0.872) | 0.598 (0.564, 0.630) | 0.585 (0.549, 0.618) | 0.597 (0.563, 0.629) | 0.583 (0.547, 0.616) |
|
| |||||||
| Liu, 2013 | Yes | CuNGAL, CuLFABP at 0h | 0.927 (0.868, 0.986) | 0.587 (0.553, 0.622)¥,# | 0.570 (0.533, 0.605)¥,# | ||
| CuNGAL, CuLFABP at 2h | 0.911 (0.836, 0.987) | 0.587 (0.551, 0.618)¥,# | 0.569 (0.535, 0.606)¥,# | ||||
|
| |||||||
| Luo, 2013 | No | uKIM1, uNGAL, uIL18 at 24h | 0.99 (0.90–1.00) | 0.654 (0.607,0.700)+ | 0.588 (0.544, 0.639)+ | 0.650 (0.603, 0.696)+ | 0.580 (0.535, 0.631)+ |
|
| |||||||
| Siew, 2013 | No | CuNGAL, CuLFABP at 0h and 48h | 0.59 (0.56–0.69) | 0.622 (0.568, 0.676)# | 0.610 (0.550, 0.661)# | 0.615 (0.560, 0.669)# | 0.602 (0.542, 0.653)# |
|
| |||||||
| Zeng, 2014 | Yes | CuNGAL at 12h, CuLFABP at 4h | 0.94 (0.89–0.98) | 0.620 (0.564, 0.675)¥,1 | 0.622 (0.561, 0.674) ¥,1 | ||
| 0.614 (0.561, 0.673)¥,2 | 0.609 (0.553, 0.668)¥,2 | ||||||
| CuNGAL at 12h, CuLFABP at 12h | 0.91 (0.85–0.97) | 0.639 (0.591, 0.686)¥,3 | 0.619 (0.561, 0.674)¥,3 | ||||
| 0.642 (0.584, 0.696)¥,4 | 0.630 (0.572, 0.687)¥,4 | ||||||
We present an overview of the studies replicated in TRIBE, including whether the paper reported the estimated combination, the biomarkers involved in the combination, the reported AUC, and the AUC in TRIBE. For the AUC in TRIBE, we considered the apparent, center-adjusted, optimism-corrected, and center-adjusted and optimism-corrected AUCs for those combinations re-estimated in TRIBE. The optimism-corrected AUC adjusts for resubstitution bias. For the combinations provided in the article, we considered the apparent and center-adjusted AUCs. The 95% confidence intervals in TRIBE were estimated by bootstrapping. Abbreviations: AUC – area under the receiver operating characteristic curve; uKIM1 – urine kidney injury marker-1; uNGAL – urine neutrophil gelatinase-associated lipocalin; CuNGAL – corrected (for urine creatinine) urine neutrophil gelatinase-associated lipocalin; pNGAL – serum neutrophil gelatinase-associated lipocalin; uIL18 – urine interleukin 18; sCr – serum creatinine; uLFABP – urine liver-type fatty acid binding protein; CuLFABP – corrected (for urine creatinine) urine liver-type fatty acid binding protein; CI – confidence interval.
Based on coefficients from paper.
Based on markers measured at 0–6h in TRIBE.
Used KIM1, IL18 and NGAL measured at day 2.
Used uNGAL at 6–12h, uLFABP at 0–6h.
Used uNGAL at 12–18h, uLFABP at 0–6h.
Used uNGAL at 6–12h, uLFABP at 6–12h.
Used uNGAL at 12–18h, uLFABP at 6–12h.