Table 3.
Renal glomerular structural characteristics of 83 participants with type 2 diabetes by TNFR1 percentiles.
| Strata of TNFR1 (percentiles) | ||||
|---|---|---|---|---|
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|
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| General Structural Variables | T1 (n=19) | T2 (n=43) | T3 (n=21) | p |
| Mean glomerular volume (×106μ3) | 5.5 (4.7-6.4) | 5.8 (4.9-6.9) | 5.4 (4.2-7.4) | 0.46 |
| Glomerular basement membrane width (nm) | 513 (367-560) | 457 (393-611) | 561 (474-649) | 0.02 |
| Cortical interstitial fractional volume (%) | 30 (28-33) | 29 (24-33) | 31 (29-35) | 0.18 |
| Mesangial fractional volume (%) | 17 (13-20) | 17 (13-23) | 27 (18-32) | 0.002 |
| Total filtration surface per glomerulus (×105μ2) | 4.2 (3.4-5.1) | 4.2 (3.5-5.6) | 3.3 (2.3-4.0) | 0.02 |
| Non-podocyte number per glomerulus) | 3171 (2066-4447) | 3696 (2705-4803) | 4010 (2991-5377) | 0.06 |
| Global glomerular sclerosis (%) | 3.3 (0-16.4) | 5.4 (0-17.7) | 10.2 (0-32.1) | 0.30 |
| Podocyte structural variables | ||||
| Podocyte number per glomerulus | 672 (518-724) | 610 (462-733) | 525 (413-725) | 0.46 |
| Filtration slit frequency (slits/mm) | 1489 (1266-1648) | 1354 (1231-1518) | 1296 (1165-1485) | 0.08 |
| Foot process width (nm) | 409 (378-499) | 470 (415-525) | 494 (430-570) | 0.02 |
| Podocyte detachment (%) | 0.28 (0-0.92) | 0.46 (0-1.07) | 0.56 (0-2.26) | 0.83 |
| Endothelial variable | ||||
| Fenestrated endothelium (%) | 31.2 (25.9-37.8) | 29.0 (22.3-33.0) | 22.9 (17.6-24.5) | <0.001 |
|
| ||||
| Strata of TNFR2 (percentiles) | ||||
|
|
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| General Structural Variables | T1 (n=21) | T2 (n=42) | T3 (n=20) | p |
|
| ||||
| Mean glomerular volume (×106μ3) | 5.5 (5.0-6.7) | 5.7 (4.5-6.8) | 5.5 (4.3-7.3) | 0.99 |
| Glomerular basement membrane width (nm) | 455 (367-556) | 503 (411-588) | 563 (448-661) | 0.06 |
| Cortical interstitial fractional volume (%) | 29 (25-33) | 30 (24-35) | 30 (26-33) | 0.87 |
| Mesangial fractional volume (%) | 15 (12-19) | 20 (14-26) | 22 (16-27) | 0.01 |
| Total filtration surface per glomerulus (×105μ2) | 4.5 (3.7-5.7) | 4.2 (3.4-5.1) | 3.4 (2.6-4.0) | 0.03 |
| Non-podocyte number per glomerulus) | 3171 (2360-4447) | 3752 (2922-4982) | 3863 (2760-4719) | 0.32 |
| Global glomerular sclerosis (%) | 3.3 (0-13.0) | 4.8 (0-16.5) | 15.1 (0-32) | 0.17 |
| Podocyte structural variables | ||||
| Podocyte number per glomerulus) | 672 (538-733) | 604 (462-724) | 551 (374-705) | 0.21 |
| Filtration slit frequency (slits/mm) | 1489 (1290-1621) | 1350 (1237-1490) | 1252 (1145-1523) | 0.03 |
| Foot process width (nm) | 415 (388-449) | 481 (428-524) | 513 (404-571) | 0.02 |
| Podocyte detachment (%) | 0.10 (0-0.77) | 0.39 (0-1.16) | 0.55 (0-1.8) | 0.64 |
| Endothelial variable | ||||
| Fenestrated endothelium (%) | 32.8 (27.6-36.1) | 26.8 (22.15-31.74) | 23.4 (18.5- 26.6) | <0.001 |
T1, TNFR1 and TNFR2 <25th percentile; T2, TNFR1 and TNFR2 25th to 75th percentile; T3, TNFR1 and TNFR2 >75th percentile.
TNFR1 values for the 25th percentile cut point=1205 pg/mL, and for the 75th percentile cut point=1960 pg/mL.
TNFR2 values for the 25th percentile cut point=2671 pg/mL, and for the 75th percentile cut point=4152 pg/mL.
Values are medians (25th and 75th centile).