Table 4.
Spearman's correlations of TNFα and TNFRs with clinical characteristics and glomerular structural parameters in 83 Pima Indians with type 2 diabetes mellitus.
| TNFR1 | TNFR2 | TNFα | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| r | p | r | p | r | p | |
| Clinical variables | ||||||
| Age (years) | 0.29 | 0.01 | 0.13 | 0.26 | -0.12 | 0.30 |
| Diabetes duration (years) | 0.24 | 0.03 | 0.20 | 0.07 | -0.17 | 0.14 |
| Mean arterial pressure (mmHg) | 0.15 | 0.16 | 0.21 | 0.06 | 0.23 | 0.04 |
| Body mass index (kg/m2) | 0.23 | 0.03 | 0.28 | 0.01 | -0.05 | 0.67 |
| A1c (%) | -0.13 | 0.25 | 0.05 | 0.66 | 0.27 | 0.02 |
| mGFR (ml/min) | -0.35 | 0.001 | -0.28 | 0.01 | 0.13 | 0.28 |
| ACR (mg/g) | 0.36 | 0.001 | 0.37 | 0.001 | 0.03 | 0.79 |
| Measured markers | ||||||
| TNFR1 | 1 | 0.84 | <0.001 | -0.14 | 0.23 | |
| TNFR2 | 0.84 | <0.001 | 1 | -0.05 | 0.69 | |
| TNFα (pg/mL) | -0.14 | 0.23 | -0.05 | 0.69 | 1 | |
|
| ||||||
| General structural variables | ||||||
| Mean glomerular volume (×106μ3) | -0.03 | 0.80 | 0.005 | 0.96 | 0.17 | 0.14 |
| Glomerular basement membrane width (nm) | 0.23 | 0.04 | 0.26 | 0.02 | 0.01 | 0.91 |
| Cortical interstitial fractional volume (%) | 0.12 | 0.28 | 0.07 | 0.54 | 0.10 | 0.38 |
| Mesangial fractional volume (%) | 0.36 | 0.001 | 0.38 | <0.001 | -0.01 | 0.91 |
| Total filtration surface per glomerulus (×105μ2) | -0.27 | 0.01 | -0.29 | 0.01 | -0.05 | 0.68 |
| Non-podocyte number per glomerulus) | 0.18 | 0.10 | 0.18 | 0.10 | 0.12 | 0.31 |
| Global glomerular sclerosis (%) | 0.25 | 0.02 | 0.18 | 0.11 | -0.19 | 0.11 |
| Podocyte structural variables | ||||||
| Podocyte number per glomerulus) | -0.23 | 0.04 | -0.16 | 0.14 | 0.15 | 0.20 |
| Filtration slit frequency (slits/mm) | -0.24 | 0.03 | -0.29 | 0.01 | -0.17 | 0.14 |
| Foot process width (nm) | 0.29 | 0.01 | 0.31 | 0.004 | 0.15 | 0.20 |
| Podocyte detachment (%) | 0.05 | 0.63 | 0.08 | 0.45 | -0.13 | 0.27 |
| Endothelial variable | ||||||
| Fenestrated endothelium (%) | -0.42 | <0.001 | -0.43 | <0.001 | 0.04 | 0.75 |
ACR, urinary albumin-to-creatinine ratio; A1c, hemoglobin A1c; mGFR, iothalamate glomerular filtration rate; r, correlation coefficient; TNFα, tumor necrosis factor α; TNFR, tumor necrosis factor receptor.